Generic placeholder image

Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Gating in Host-Guest Chemistry

Author(s): Fang Liu, Hao Wang and Kendall N. Houk

Volume 17, Issue 14, 2013

Page: [1470 - 1480] Pages: 11

DOI: 10.2174/1385272811317140003

Abstract

Gating in host-guest chemistry refers to conformational changes that occur in response to some stimulus, resulting in opening or closing of a physical barrier that controls access to the host. Gating due to conformational changes of protein loops is common in enzyme catalysts: the binding of a substrate in an enzyme often involves the closing of a protein loop to bind the substrate, a type of gating [1]. Cram’s pioneering work in host-guest chemistry led to the discovery of one molecule inside another and the concept of container molecules. Cram’s nanometer-scaled container molecules were found by our group to involve gating to allow passage of guest molecules into or out of the container host [2]. The gating process in container molecules provides a novel way that binding and release of guest molecules can be controlled, and this has potential applications in controlled drug delivery.

Keywords: Gating, Host-guest chemistry.


© 2024 Bentham Science Publishers | Privacy Policy