Abstract
Chiral sulfoxides are extensively used in synthesis of chiral drugs, total synthesis of natural products and organic synthesis. Among them, chiral sulfoxide drugs in market or under research mostly have nitrogen-containing substructures. In common titanium catalysts have better catalytic property in asymmetric oxidation of these nitrogencontaining sulfide precursors than other catalysts. The ligands of these titanium catalysts have tartarate, BINOL and other diols, salens and others. Proton pump inhibitors, anti-inflammatory drugs, anti-cancer drugs, antibiotics, platelet adhesion inhibitors, antipsychotic drugs, lipid regulators, potassium channel openers, neurokinin inhibitors and so on are valuable chiral sulfoxide drugs. The research advances of synthesis of various chiral sulfoxide drugs catalyzed by titanium are described in this review.
Keywords: Titanium catalyst, asymmetric catalysis, sulfide oxidation; chiral sulfoxides, chiral drugs.
Mini-Reviews in Organic Chemistry
Title:Advances in Titanium-Catalyzed Synthesis of Chiral Sulfoxide Drugs
Volume: 10 Issue: 2
Author(s): Qingle Zeng, Shan Gao and Allan Kipruto Chelashaw
Affiliation:
Keywords: Titanium catalyst, asymmetric catalysis, sulfide oxidation; chiral sulfoxides, chiral drugs.
Abstract: Chiral sulfoxides are extensively used in synthesis of chiral drugs, total synthesis of natural products and organic synthesis. Among them, chiral sulfoxide drugs in market or under research mostly have nitrogen-containing substructures. In common titanium catalysts have better catalytic property in asymmetric oxidation of these nitrogencontaining sulfide precursors than other catalysts. The ligands of these titanium catalysts have tartarate, BINOL and other diols, salens and others. Proton pump inhibitors, anti-inflammatory drugs, anti-cancer drugs, antibiotics, platelet adhesion inhibitors, antipsychotic drugs, lipid regulators, potassium channel openers, neurokinin inhibitors and so on are valuable chiral sulfoxide drugs. The research advances of synthesis of various chiral sulfoxide drugs catalyzed by titanium are described in this review.
Export Options
About this article
Cite this article as:
Zeng Qingle, Gao Shan and Chelashaw Kipruto Allan, Advances in Titanium-Catalyzed Synthesis of Chiral Sulfoxide Drugs, Mini-Reviews in Organic Chemistry 2013; 10 (2) . https://dx.doi.org/10.2174/1570193X11310020008
DOI https://dx.doi.org/10.2174/1570193X11310020008 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pharmacophore, Similarity and ADMET Screening of Casein Kinase 1 inhibitors in Alzheimer's Disease
Current Bioactive Compounds Peptides for Therapy and Diagnosis of Alzheimer's Disease
Current Pharmaceutical Design Arterial Dilatation-Related Diseases: The Prerequisite Condition of Arterial Elastic Tissue Damage and Endovascular Treatment
Recent Patents on Medical Imaging Meet Our Editorial Board Member
Protein & Peptide Letters Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and in Siblings
Endocrine, Metabolic & Immune Disorders - Drug Targets Farnesyltransferase Inhibitors: Overview of their Action and Role in Solid Malignancy Therapy
Letters in Drug Design & Discovery Understanding Genetic Factors in Idiopathic Scoliosis, a Complex Disease of Childhood
Current Genomics Progress in Research of K<sub>V</sub>1.1 and K<sub>V</sub>1.3 Channels as Therapeutic Targets
Current Topics in Medicinal Chemistry Arthritis and Periodontitis: An Association Debated for Over Two Centuries
Current Rheumatology Reviews The Cardiovascular Nutrapharmacology of Resveratrol: Pharmacokinetics, Molecular Mechanisms and Therapeutic Potential
Current Medicinal Chemistry Hypoxia Inducible Factor-1α, Endothelial Progenitor Cells, Monocytes,Cardiovascular Risk, Wound Healing, Cobalt and Hydralazine:A Unifying Hypothesis
Current Drug Targets Trans-diagnostic Validation in Neuro-psychiatry: Towards Biological Signatures of Disease
Current Topics in Medicinal Chemistry Distribution of Chloroaluminum Phthalocyanine in a Lipid Nano-Emulsion as Studied by Second-Derivative Spectrophotometry
Micro and Nanosystems Polyphenols as Potential Inhibitors of Amyloid Aggregation and Toxicity:Possible Significance to Alzheimers Disease
Mini-Reviews in Medicinal Chemistry Contribution of Mast Cells to Cerebral Aneurysm Formation
Current Neurovascular Research Nitric Oxide and Inflammation
Inflammation & Allergy - Drug Targets (Discontinued) Can Cannabis Increase the Suicide Risk in Psychosis? A Critical Review
Current Pharmaceutical Design The Problem of False-Positive Human Papillomavirus DNA Tests in Cervical Screening
Current Pharmaceutical Design Managing Skin Malignancies- How Family Doctors, Plastic Surgeons, and Dermatologists Can Help
Current Cancer Therapy Reviews Cognitive Behavioral Therapy for Psychosis Prevention and Treatment in Youth
Current Psychiatry Reviews