New Development and Application of Ultrasound Targeted Microbubble Destruction in Gene Therapy and Drug Delivery

Zhi-Yi      Chen; Feng      Yang; Yan      Lin; Jin-Shan      Zhang; Ri-Xiang      Qiu; Lan      Jiang; Xing-Xing      Zhou; Jiang-Xiu      Yu

Abstract

Ultrasound is a common used technique for clinical imaging. In recent years, with the advances in preparation technology of microbubbles and the innovations in ultrasound imaging, ultrasound is no longer confined to detection of tissue perfusion, but extends to specific ultrasound molecular imaging and target therapy gradually. With the development of research, ultrasound molecular imaging and target therapy have made great progresses. Targeted microbubbles for molecular imaging are achieved by binding target molecules, specific antibody or ligand to the surface of microbubbles to obtain specific imaging by attaching to target tissues. Meanwhile, it can also achieve targeting gene therapy or drug delivery by ultrasound targeted microbubble destruction (UTMD) mediating genes or drugs to specific target sites. UTMD has a number of advantages, such as target-specific, highly effective, non-invasivity, relatively low-cost and no radiation, and has broad application prospects, which is regarded as one hot spot in medical studies. We reviewed the new development and application of UTMD in gene therapy and drug delivery in this paper. With further development of technology and research, the gene or drug delivery system and related methods will be widely used in application and researches.

Keywords: Ultrasound, microbubble, gene therapy, drug delivery, application.

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