Abstract
Owing to their ability in destroying or slowing down the growth of bacteria, antibiotics have been widely used to treat the bacterial infections. However, because of the long-term and irresponsible use of antibiotics, resistance to antibiotics has become a serious problem directly threatening the public health worldwide. To fight against and resist β- lactam antibiotics, bacteria usually employed β-lactamases, especially the metallo-β-lactamases, to hydrolyze the C-N bond of the β-lactam ring so as to inactivate the antibiotics. In this minireview, we are to summarize the structural features of the metallo-β-lactamases, as well as their antibiotic binding modes and resistance mechanisms, in hopes that the discussion and analysis presented in this paper can stimulate new strategies to overcome the resistance problem and find novel inhibitors against the metallo-β-lactamases.
Keywords: β-Lactamase; antibiotics; resistance; new Delhi metallo-β-lactamase.
Current Topics in Medicinal Chemistry
Title:Metallo-β-Lactamases: Structural Features, Antibiotic Recognition, Inhibition, and Inhibitor Design
Volume: 13 Issue: 10
Author(s): Jing-Fang Wang and Kuo-Chen Chou
Affiliation:
Keywords: β-Lactamase; antibiotics; resistance; new Delhi metallo-β-lactamase.
Abstract: Owing to their ability in destroying or slowing down the growth of bacteria, antibiotics have been widely used to treat the bacterial infections. However, because of the long-term and irresponsible use of antibiotics, resistance to antibiotics has become a serious problem directly threatening the public health worldwide. To fight against and resist β- lactam antibiotics, bacteria usually employed β-lactamases, especially the metallo-β-lactamases, to hydrolyze the C-N bond of the β-lactam ring so as to inactivate the antibiotics. In this minireview, we are to summarize the structural features of the metallo-β-lactamases, as well as their antibiotic binding modes and resistance mechanisms, in hopes that the discussion and analysis presented in this paper can stimulate new strategies to overcome the resistance problem and find novel inhibitors against the metallo-β-lactamases.
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Cite this article as:
Wang Jing-Fang and Chou Kuo-Chen, Metallo-β-Lactamases: Structural Features, Antibiotic Recognition, Inhibition, and Inhibitor Design, Current Topics in Medicinal Chemistry 2013; 13 (10) . https://dx.doi.org/10.2174/15680266113139990011
DOI https://dx.doi.org/10.2174/15680266113139990011 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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