New Class of Pyrimidinesulfamoyl Containing Pyrazole and Pyrrole Derivatives and Their Antioxidant Activity

Title:New Class of Pyrimidinesulfamoyl Containing Pyrazole and Pyrrole Derivatives and Their Antioxidant Activity

Volume: 10 Issue: 5

Author(s): Suresh Maddila and Sreekanth B. Jonnalagadda

Affiliation:

Keywords: Antioxidant activity, synthesis, pyrimidin-2-yl-sulfamoyl-cinnamamide, pyrrole-3-carboxamides, pyrazole-3- carboxamides.

Abstract: A new series of pyrimidinesulfamoyl-1H-pyrrole-3-carboxamides (3a-e) and pyrimidinesulfamoyl-1Hpyrazole- 3-carboxamides (4a-e) moiety was prepared using intermediate compounds pyrimidinesulfamoyl cinnamamides (2a-e). On the basis of the FT-IR, 1H NMR, 13C NMR, LCMS spectral results and elemental analysis data, the structures of newly synthesized compounds were confirmed. Based on results of their in-vitro antioxidant activities, compounds such as 3b, 3c and 3d exhibited promising antioxidant activities and while remaining compounds such as 4c, 4b, 3a, 4d, 4a, 3e, 4e and 2c showed moderate to good antioxidant activity.

Cite this article as:

Maddila Suresh and Jonnalagadda Sreekanth B., New Class of Pyrimidinesulfamoyl Containing Pyrazole and Pyrrole Derivatives and Their Antioxidant Activity, Letters in Organic Chemistry 2013; 10 (5) . https://dx.doi.org/10.2174/1570178611310050013