Abstract
Polyethylene glycol (PEG) encapsulation of porphyrin was designed and synthesized by introducing branched PEG substituents to the porphyrin core. Fluorescence imaging of cells was conducted to investigate the cellular uptake of these PEPPs. Results suggest that the porphyrin compound with 16 triethylene glycol chains exhibits increased cellular uptake and/or efficiency for emitting fluorescence inside the cells. The singlet oxygen yield of the porphyrin compound with 16 triethylene glycol chains is determined to be 0.93. This high singlet oxygen yield may be attributed to the large number of polyethylene glycol chains that hinder aggregation and excited-state quenching. PEPPs exhibit potential as a new class of photosensitizers for photodynamic therapy because of their water solubility, good biocompatibility, and high singlet oxygen yield.
Keywords: Porphyrins, photosensitizers, singlet oxygen yields, fluorescence imaging.
Letters in Organic Chemistry
Title:PEG Encapsulation of Porphyrins for Cell Imaging and Photodynamic Therapy
Volume: 10 Issue: 5
Author(s): Jinjun Liu, Licui Zhang, Xiaojuan Du, Fengxia Cui, Chunlei Du and Baoxiang Gao
Affiliation:
Keywords: Porphyrins, photosensitizers, singlet oxygen yields, fluorescence imaging.
Abstract: Polyethylene glycol (PEG) encapsulation of porphyrin was designed and synthesized by introducing branched PEG substituents to the porphyrin core. Fluorescence imaging of cells was conducted to investigate the cellular uptake of these PEPPs. Results suggest that the porphyrin compound with 16 triethylene glycol chains exhibits increased cellular uptake and/or efficiency for emitting fluorescence inside the cells. The singlet oxygen yield of the porphyrin compound with 16 triethylene glycol chains is determined to be 0.93. This high singlet oxygen yield may be attributed to the large number of polyethylene glycol chains that hinder aggregation and excited-state quenching. PEPPs exhibit potential as a new class of photosensitizers for photodynamic therapy because of their water solubility, good biocompatibility, and high singlet oxygen yield.
Export Options
About this article
Cite this article as:
Liu Jinjun, Zhang Licui, Du Xiaojuan, Cui Fengxia, Du Chunlei and Gao Baoxiang, PEG Encapsulation of Porphyrins for Cell Imaging and Photodynamic Therapy, Letters in Organic Chemistry 2013; 10 (5) . https://dx.doi.org/10.2174/1570178611310050007
DOI https://dx.doi.org/10.2174/1570178611310050007 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Thalidomide Analogues as Anticancer Drugs
Recent Patents on Anti-Cancer Drug Discovery Erythropoietin and mTOR: A “One-Two Punch” for Aging-Related Disorders Accompanied by Enhanced Life Expectancy
Current Neurovascular Research Synthesis and Cellular Pharmacology Studies of a Series of 2-amino-3-aroyl-4-substituted Thiophene Derivatives
Medicinal Chemistry Expression Profiling of Estrogen Responsive Genes Using Genomic and Proteomic Techniques for the Evaluation of Endocrine Disruptors
Current Pharmacogenomics Lentisk (<i>Pistacia lentiscus L.</i>) a Renewable Source of Pure Shikimic Acid and its Antioxidant Activity
Current Bioactive Compounds Evolution of Novel Non-Steroidal Anti-Inflammatory Drugs with Reduced Gastrointestinal Adverse Effects
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry BDNF/NF-κB Signaling in the Neurobiology of Depression
Current Pharmaceutical Design Hemodynamic Assessment and In vivo Catabolism of Adenosine 5’-triphosphate in Doxorubicin or Isoproterenol-induced Cardiovascular Toxicity
Drug Metabolism Letters Structural Heterogeneity and Multifunctionality of Lactoferrin
Current Protein & Peptide Science Fullerenes for Cancer Diagnosis and Therapy: Preparation, Biological and Clinical Perspectives
Current Drug Metabolism An Efficient Synthesis of the 2H-pyrano[3,2-c]quinoline-2,5(6H)-dione System via Tandem Reaction of 4-hydroxyquinolinones to Baylis-Hillman Adduct Acetates
Letters in Organic Chemistry Heterologous Production of Death Ligands’ and Death Receptors’ Extracellular Domains: Structural Features and Efficient Systems
Protein & Peptide Letters Synthesis and Biological Evaluation of Novel Antifolate Analogs as Potential Anticancer Treatment
Anti-Cancer Agents in Medicinal Chemistry Synthesis of Some Novel 4-(Arylideneamino)-N'-((2-chloro-8-methylquinolin- 3-yl)methylene)-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carbohydrazides as Potential Antimicrobial Agents
Letters in Drug Design & Discovery Toward a Discipline of Pharmacoepigenomics
Current Pharmacogenomics Studies on Two New Mixed Ligand Platinum Compounds with a Trans- Geometry
Medicinal Chemistry Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls
Current Psychiatry Reviews Raman Spectroscopy and Imaging: Promising Optical Diagnostic Tools in Pediatrics
Current Medicinal Chemistry Deubiquitinating Enzymes as Promising Drug Targets for Infectious Diseases
Current Pharmaceutical Design Synthesis and Urease Inhibitory Activity of Some 5-Aminomethylene Barbituric/Thiobarbituric Acid Derivatives
Letters in Drug Design & Discovery