Abstract
A collection of both commercial and non-commercial galloyl derivatives (either isolated from plants or synthesized) was examined for an in vitro structure-activity relationship (SAR) screening of their anti-yeast activity. Most of the compounds exhibited an antimycotic activity when used together with amphotericin B (AMB) and none when used alone. The SAR study indicated the presence of two galloyl moieties in adjacent position as an important structural characteristic. In fact, among the compounds tested, 2,3-O-digalloyl-O-methylglucose and 2,3-O-digalloyl-Omethylmannose exhibited a synergistic interaction with AMB against a set of Candida albicans, Candida glabrata and Pichia kudriavzevii strains. A similar biological activity has also been observed for epigallocatechin gallate (EGCG). The high structural similarity between the two digalloyl derivatives and EGCG was advocated as possible rationale to explain their synergy with AMB.
Keywords: Anti-yeast activity, FIC, gallic acid, glucogalloy derivatives, MIC, SAR, synergy.
The Natural Products Journal
Title:In Vitro Synergistic Anti-yeast Activity between Galloyl Derivatives and Amphotericin B
Volume: 3 Issue: 2
Author(s): Panagiotis Arapitsas, Benedetta Turchetti, Fabrizio Melani, Daniela Tacconi, Cristina Nativi, Annalisa Romani, Stefano Menichetti and Pietro Buzzini
Affiliation:
Keywords: Anti-yeast activity, FIC, gallic acid, glucogalloy derivatives, MIC, SAR, synergy.
Abstract: A collection of both commercial and non-commercial galloyl derivatives (either isolated from plants or synthesized) was examined for an in vitro structure-activity relationship (SAR) screening of their anti-yeast activity. Most of the compounds exhibited an antimycotic activity when used together with amphotericin B (AMB) and none when used alone. The SAR study indicated the presence of two galloyl moieties in adjacent position as an important structural characteristic. In fact, among the compounds tested, 2,3-O-digalloyl-O-methylglucose and 2,3-O-digalloyl-Omethylmannose exhibited a synergistic interaction with AMB against a set of Candida albicans, Candida glabrata and Pichia kudriavzevii strains. A similar biological activity has also been observed for epigallocatechin gallate (EGCG). The high structural similarity between the two digalloyl derivatives and EGCG was advocated as possible rationale to explain their synergy with AMB.
Export Options
About this article
Cite this article as:
Arapitsas Panagiotis, Turchetti Benedetta, Melani Fabrizio, Tacconi Daniela, Nativi Cristina, Romani Annalisa, Menichetti Stefano and Buzzini Pietro, In Vitro Synergistic Anti-yeast Activity between Galloyl Derivatives and Amphotericin B, The Natural Products Journal 2013; 3 (2) . https://dx.doi.org/10.2174/2210315511303020008
DOI https://dx.doi.org/10.2174/2210315511303020008 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Editorial [Hot Topic: ADAMs: Targets for Drug Discovery (Executive Editor: Marcia L. Moss)]
Current Pharmaceutical Design Heat Shock Proteins: Therapeutic Perspectives in Inflammatory Disorders
Recent Patents on Inflammation & Allergy Drug Discovery Protective Effects of Astragalus Membranaceus and Ligustrazine on Rat Brain Microvascular Endothelial Cell Injury after Oxygen-Glucose Deprivation/ Reoxygenation by Suppressing the PKCδ/MARCKS Pathway
Combinatorial Chemistry & High Throughput Screening Recent Progress Toward Hydrogen Medicine: Potential of Molecular Hydrogen for Preventive and Therapeutic Applications
Current Pharmaceutical Design Food and Food Supplements with Hypocholesterolemic Effects
Recent Patents on Food, Nutrition & Agriculture Structural Characterization, Biological Effects, and Synthetic Studies on Xanthones from Mangosteen (Garcinia mangostana), a Popular Botanical Dietary Supplement
Mini-Reviews in Organic Chemistry Regulation of Intestinal Barrier Function by Dietary Polyphenols
Current Nutrition & Food Science Re-Balancing of Inflammation and Aβ Immunity as a Therapeutic for Alzheimers Disease-View from the Bedside
CNS & Neurological Disorders - Drug Targets Novel Biomarkers Assessing Endothelial Dysfunction: Role of microRNAs
Current Topics in Medicinal Chemistry Evaluation and Management of Asymptomatic Bradyarrhythmias
Current Cardiology Reviews Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches
CNS & Neurological Disorders - Drug Targets Bioprospecting for Functionally-Proficient Potential Probiotics
Current Nutrition & Food Science The Role of Hesperidin in Cell Signal Transduction Pathway for the Prevention or Treatment of Cancer
Current Medicinal Chemistry Novel Drug Targets in Malaria Parasite with Potential to Yield Antimalarial Drugs with Long Useful Therapeutic Lives
Current Pharmaceutical Design A Review of Epidemiological Evidence on Short-Term Effects of Environmental Factors on Respiratory Problems in Children
Current Respiratory Medicine Reviews Regulation of Cardiac Calcium Channels in the Fight-or-Flight Response
Current Molecular Pharmacology Selective Toxicity of Apigenin on Cancerous Hepatocytes by Directly Targeting their Mitochondria
Anti-Cancer Agents in Medicinal Chemistry MicroRNAs as Modulators of the Platelet Proteome
Current Proteomics Neuropsychiatric Disturbances in Alzheimer’s Disease: What Have We Learned from Neuropathological Studies?
Current Alzheimer Research Chitosan and Its Use in Design of Insulin Delivery System
Recent Patents on Drug Delivery & Formulation