Abstract
MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate, high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAs have begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions between circulating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On the other hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulating miRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progress in identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatory bowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs in the care of inflammatory diseases.
Keywords: Asthma, biomarkers, circulating markers, inflammatory bowl disease, microRNA, rheumatoid arthritis.
MicroRNA
Title:Circulating MicroRNAs as Biomarkers for Inflammatory Diseases
Volume: 2 Issue: 1
Author(s): Shuangli Mi, Jian Zhang, Wei Zhang and R. Stephanie Huang
Affiliation:
Keywords: Asthma, biomarkers, circulating markers, inflammatory bowl disease, microRNA, rheumatoid arthritis.
Abstract: MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate, high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAs have begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions between circulating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On the other hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulating miRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progress in identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatory bowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs in the care of inflammatory diseases.
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Cite this article as:
Mi Shuangli, Zhang Jian, Zhang Wei and Huang R. Stephanie, Circulating MicroRNAs as Biomarkers for Inflammatory Diseases, MicroRNA 2013; 2 (1) . https://dx.doi.org/10.2174/2211536611302010007
DOI https://dx.doi.org/10.2174/2211536611302010007 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
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