Abstract
It is clear now that proteins lacking ordered structure, generally known as intrinsically disordered proteins (IDPs), possess numerous biological functions that complement functional repertoires of ordered proteins. IDPs are common in nature, and abundantly found to be involved in the pathogenesis of various diseases. These proteins participate in various biological processes and play crucial roles in regulation of functions of their binding partners. Often, disorder-to-order transition induced by the IDP binding to a specific partner defines the low-affinity – high-specificity signaling interactions. Although many IDPs undergo a disorder-to-order transition upon binding, large fraction of IDPs can preserve significant amount of disorder even in their bound states. IDPs can participate in one-tomany and many-to-one interactions, where one intrinsically disordered protein region (IDPR) binds to multiple partners potentially gaining very different structures in the bound state, or where multiple unrelated IDPs/IDPRs bind to one partner. Binding functions of IDPs and IDPRs are controlled by various means, such as numerous posttranslational modifications and alternative splicing. Some of the aspects of the intrinsic disorder-based protein interactions and modes of their regulation are considered in this review.
Keywords: Intrinsically disordered protein, protein-protein interaction, posttranslational modification, alternative splicing, structure-function relationship, hub proteins.
Current Pharmaceutical Design
Title:Intrinsic Disorder-based Protein Interactions and their Modulators
Volume: 19 Issue: 23
Author(s): Vladimir N. Uversky
Affiliation:
Keywords: Intrinsically disordered protein, protein-protein interaction, posttranslational modification, alternative splicing, structure-function relationship, hub proteins.
Abstract: It is clear now that proteins lacking ordered structure, generally known as intrinsically disordered proteins (IDPs), possess numerous biological functions that complement functional repertoires of ordered proteins. IDPs are common in nature, and abundantly found to be involved in the pathogenesis of various diseases. These proteins participate in various biological processes and play crucial roles in regulation of functions of their binding partners. Often, disorder-to-order transition induced by the IDP binding to a specific partner defines the low-affinity – high-specificity signaling interactions. Although many IDPs undergo a disorder-to-order transition upon binding, large fraction of IDPs can preserve significant amount of disorder even in their bound states. IDPs can participate in one-tomany and many-to-one interactions, where one intrinsically disordered protein region (IDPR) binds to multiple partners potentially gaining very different structures in the bound state, or where multiple unrelated IDPs/IDPRs bind to one partner. Binding functions of IDPs and IDPRs are controlled by various means, such as numerous posttranslational modifications and alternative splicing. Some of the aspects of the intrinsic disorder-based protein interactions and modes of their regulation are considered in this review.
Export Options
About this article
Cite this article as:
Uversky Vladimir N., Intrinsic Disorder-based Protein Interactions and their Modulators, Current Pharmaceutical Design 2013; 19 (23) . https://dx.doi.org/10.2174/1381612811319230005
DOI https://dx.doi.org/10.2174/1381612811319230005 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Quinoline as a Privileged Scaffold in Cancer Drug Discovery
Current Medicinal Chemistry The Advance of Dendrimers - A Versatile Targeting Platform for Gene/Drug Delivery
Current Pharmaceutical Design Integrins in Drug Targeting-RGD Templates in Toxins
Current Pharmaceutical Design Semicarbazide-Sensitive Amine Oxidase/Vascular Adhesion Protein 1: Recent Developments Concerning Substrates and Inhibitors of a Promising Therapeutic Target
Current Medicinal Chemistry Natural Compounds and Plant Extracts as Therapeutics Against Chronic Inflammation in Alzheimer's Disease - A Translational Perspective
CNS & Neurological Disorders - Drug Targets Emerging Therapies Targeting Tumor Vasculature in Multiple Myeloma and other Hematologic and Solid Malignancies
Current Cancer Drug Targets The Caveolin-1 Connection to Cell Death and Survival
Current Molecular Medicine Psychosocial Factors and Central Sensitivity Syndromes
Current Rheumatology Reviews Uropathogenic Escherichia coli Mediated Urinary Tract Infection
Current Drug Targets Nitric Oxide and Dietary Factors: Part II Cholesterol, Fat, Amino Acids,Proteins and Carbohydrate
Vascular Disease Prevention (Discontinued) Exploring Pharmacological Significance of Chalcone Scaffold: A Review
Current Medicinal Chemistry Anti-VEGF Drugs in Eye Diseases: Local Therapy with Potential Systemic Effects
Current Pharmaceutical Design Clinical Management of Diabetes Mellitus in the Older Adult Patient
Current Diabetes Reviews Clinical Implications of Recent Insights into the Structural Biology of Beta2 Adrenoceptors
Current Drug Targets In Vivo Angiogenesis and Lymphangiogenesis Models
Current Molecular Medicine A Brief Review on Breast Carcinoma and Deliberation on Current Non Invasive Imaging Techniques for Detection
Current Medical Imaging From Adipose Tissue Protein Secretion to Adipopharmacology of Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The MCM Complex: Its Role in DNA Replication and Implications for Cancer Therapy
Current Cancer Drug Targets HPV and Therapeutic Vaccines: Where are We in 2010?
Current Cancer Therapy Reviews Review of Medicinal Plants Common to Traditional Chinese and Indian Medicines with Relevance to Non-Communicable Diseases
Current Traditional Medicine