Abstract
3-Chlorobenzoic acid hydrazide was reacted with different aryl isothiocyanates to give the corresponding 1-(3- chlorobenzoyl)-4-substituted thiosemicarbazides 1-16. Reaction yields ranged from 74 to 96%. Structures of the synthesized compounds were defined on the basis of 1H NMR and IR spectra. As it was showed the antibacterial activity of the obtained compounds was limited only towards Gram-positive bacteria. As regards B. cereus ATCC 10876, 1-(3- chlorobenzoyl)-4-(3,5-dichlorophenyl)thiosemicarbazide (8) was 16 times more active than ampicillin and 8 times more active than cefuroxime.
Keywords: Hydrazides, Structure-activity relationships, MIC, MRSA.
Letters in Drug Design & Discovery
Title:Diversity in Antibacterial Activity of Thiosemicarbazides Derived from 3-Chlorobenzhydrazide
Volume: 10 Issue: 6
Author(s): Tomasz Plech, Monika Wujec, Urszula Kosikowska and Anna Malm
Affiliation:
Keywords: Hydrazides, Structure-activity relationships, MIC, MRSA.
Abstract: 3-Chlorobenzoic acid hydrazide was reacted with different aryl isothiocyanates to give the corresponding 1-(3- chlorobenzoyl)-4-substituted thiosemicarbazides 1-16. Reaction yields ranged from 74 to 96%. Structures of the synthesized compounds were defined on the basis of 1H NMR and IR spectra. As it was showed the antibacterial activity of the obtained compounds was limited only towards Gram-positive bacteria. As regards B. cereus ATCC 10876, 1-(3- chlorobenzoyl)-4-(3,5-dichlorophenyl)thiosemicarbazide (8) was 16 times more active than ampicillin and 8 times more active than cefuroxime.
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Plech Tomasz, Wujec Monika, Kosikowska Urszula and Malm Anna, Diversity in Antibacterial Activity of Thiosemicarbazides Derived from 3-Chlorobenzhydrazide, Letters in Drug Design & Discovery 2013; 10 (6) . https://dx.doi.org/10.2174/1570180811310060004
DOI https://dx.doi.org/10.2174/1570180811310060004 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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