Abstract
Microfluidic systems provide powerful tools for controlling the in vitro cellular microenvironment which best mimick the in vivo biological matrix. Such devices have been applied to both temporal and spatial manipulation of cell growth and stimuli by micro-scaled channels, patterns, and fluidic systems, creating new opportunities for biologists to study cellular behaviors under different physical and chemical conditions. In this paper, we review the concepts and strategies in designing microfluidic devices for culturing, manipulating, and stimulating cells under well-established microenvironments. We further discuss their various biological applications and potential integrations with other observation- based systems.
Keywords: Microfluidic, Cell culture, Lap-on-chip, Chemotaxis, Electrotaxis, Super-resolution microscopy.
Micro and Nanosystems
Title:Cell Culture in Microfluidic Systems
Volume: 5 Issue: 2
Author(s): Yung-Shin Sun and Ji-Yen Cheng
Affiliation:
Keywords: Microfluidic, Cell culture, Lap-on-chip, Chemotaxis, Electrotaxis, Super-resolution microscopy.
Abstract: Microfluidic systems provide powerful tools for controlling the in vitro cellular microenvironment which best mimick the in vivo biological matrix. Such devices have been applied to both temporal and spatial manipulation of cell growth and stimuli by micro-scaled channels, patterns, and fluidic systems, creating new opportunities for biologists to study cellular behaviors under different physical and chemical conditions. In this paper, we review the concepts and strategies in designing microfluidic devices for culturing, manipulating, and stimulating cells under well-established microenvironments. We further discuss their various biological applications and potential integrations with other observation- based systems.
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Cite this article as:
Sun Yung-Shin and Cheng Ji-Yen, Cell Culture in Microfluidic Systems, Micro and Nanosystems 2013; 5 (2) . https://dx.doi.org/10.2174/1876402911305020002
DOI https://dx.doi.org/10.2174/1876402911305020002 |
Print ISSN 1876-4029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1876-4037 |
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