Abstract
Synthesis of the functionalized silica-coated magnetic nanoparticles (Si-MNPs) was achieved with organic/inorganic hybrids and approached for high throughput biomolecular separation. To increase the reactivity between biomolecules and Si-MNPs, organic/ inorganic hybrid functionalization has been obtained through the coupling of organosilanes, having various organic residues, with free sianol groups of the silica surfaces. This review gives an overview of the preparation, properties, and current applications of the materials in the areas of immunomagnetic and enzymatic separations as well as biomolecule separations, with the main focus being on Si- MNPs. The organic/inorganic hybrid functionalized Si-MNPs allow the development of sophisticated nanoscale separation systems for bioanalytical, biosensor-based, clinical and environmental applications.
Keywords: Magnetic Nanoparticles, Bio-separation, DNA, Protein, Enzyme.
Current Organic Chemistry
Title:Organic/Inorganic Hybrid Functionalized Magnetic Nanoparticles for High Throughput Biomolecular Separation
Volume: 17 Issue: 10
Author(s): Jeong H. Chang, Soo Y. Lee and Jiho Lee
Affiliation:
Keywords: Magnetic Nanoparticles, Bio-separation, DNA, Protein, Enzyme.
Abstract: Synthesis of the functionalized silica-coated magnetic nanoparticles (Si-MNPs) was achieved with organic/inorganic hybrids and approached for high throughput biomolecular separation. To increase the reactivity between biomolecules and Si-MNPs, organic/ inorganic hybrid functionalization has been obtained through the coupling of organosilanes, having various organic residues, with free sianol groups of the silica surfaces. This review gives an overview of the preparation, properties, and current applications of the materials in the areas of immunomagnetic and enzymatic separations as well as biomolecule separations, with the main focus being on Si- MNPs. The organic/inorganic hybrid functionalized Si-MNPs allow the development of sophisticated nanoscale separation systems for bioanalytical, biosensor-based, clinical and environmental applications.
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Cite this article as:
H. Chang Jeong, Lee Y. Soo and Lee Jiho, Organic/Inorganic Hybrid Functionalized Magnetic Nanoparticles for High Throughput Biomolecular Separation, Current Organic Chemistry 2013; 17 (10) . https://dx.doi.org/10.2174/1385272811317100003
DOI https://dx.doi.org/10.2174/1385272811317100003 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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