Abstract
Metallothionein (MT) is a low molecular weight metal-binding protein induced by endogenous and exogenous stimuli such as cytokines and heavy metals. In 1993 and 1994, two research groups (Choo et al. and Palmiter et al., respectively) produced MT-I/II double-knockout mice (MT-I/II null mice) with null mutations of the MT-I and MT-II genes. Subsequently, MT-I/II null mice have been used to clarify the biological function, physiological role, and pathophysiological relevance of MT by many research groups. Recent studies using MT-I/II null mice to investigate the role of MT in metal toxicity and distribution, oxidative stress, and some disease were reviewed. In addition, several research groups including our laboratory have reported that MT-I/II null mice are highly susceptible to several carcinogenesis caused by 7,12-dimethylbenz[a]anthracene, X-ray, benzo[a]pyrene, N-butyl-N-(4-hydroxybutyl) nitrosamine, lead, and cisplatin. These results suggest that MT is an important protective factor against not only metal toxicity and oxidative stress but also chemical and radiation carcinogenesis. In this review, we present the findings of MT-I/II null mice with regard to the protective role of MT in carcinogenesis and mutagenesis caused by chemical agents and X-ray.
Keywords: Carcinogen, carcinogenesis, knockout mice, metallothionein, mutagenesis, radiation.
Current Pharmaceutical Biotechnology
Title:Protective Role of Metallothionein in Chemical and Radiation Carcinogenesis
Volume: 14 Issue: 4
Author(s): Yasuyuki Fujiwara and Masahiko Satoh
Affiliation:
Keywords: Carcinogen, carcinogenesis, knockout mice, metallothionein, mutagenesis, radiation.
Abstract: Metallothionein (MT) is a low molecular weight metal-binding protein induced by endogenous and exogenous stimuli such as cytokines and heavy metals. In 1993 and 1994, two research groups (Choo et al. and Palmiter et al., respectively) produced MT-I/II double-knockout mice (MT-I/II null mice) with null mutations of the MT-I and MT-II genes. Subsequently, MT-I/II null mice have been used to clarify the biological function, physiological role, and pathophysiological relevance of MT by many research groups. Recent studies using MT-I/II null mice to investigate the role of MT in metal toxicity and distribution, oxidative stress, and some disease were reviewed. In addition, several research groups including our laboratory have reported that MT-I/II null mice are highly susceptible to several carcinogenesis caused by 7,12-dimethylbenz[a]anthracene, X-ray, benzo[a]pyrene, N-butyl-N-(4-hydroxybutyl) nitrosamine, lead, and cisplatin. These results suggest that MT is an important protective factor against not only metal toxicity and oxidative stress but also chemical and radiation carcinogenesis. In this review, we present the findings of MT-I/II null mice with regard to the protective role of MT in carcinogenesis and mutagenesis caused by chemical agents and X-ray.
Export Options
About this article
Cite this article as:
Fujiwara Yasuyuki and Satoh Masahiko, Protective Role of Metallothionein in Chemical and Radiation Carcinogenesis, Current Pharmaceutical Biotechnology 2013; 14 (4) . https://dx.doi.org/10.2174/1389201011314040002
DOI https://dx.doi.org/10.2174/1389201011314040002 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Overview on Inhalable Nanocarriers for Respiratory Immunization
Current Pharmaceutical Design Pivotal Roles of Interleukin-17 as the Epicenter of Bone Loss Diseases
Current Pharmaceutical Design Applications of Animal Models of Infectious Arthritis in Drug Discovery:A focus on Alphaviral Disease
Current Drug Targets STING Activation and its Application in Immuno-Oncology
Current Topics in Medicinal Chemistry Recent Advances in Antiviral Agents: Established and Innovative Therapies for Viral Hepatitis
Mini-Reviews in Medicinal Chemistry Modulation of the Type I Interferon Response Defines the Sensitivity of Human Melanoma Cells to Oncolytic Measles Virus
Current Gene Therapy P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives
Current Cancer Drug Targets Membrane Lipid Domains: Techniques for Visualization and Characterization
Current Analytical Chemistry Fluoride Effects: The Two Faces of Janus
Current Medicinal Chemistry Rasburicase: A New Approach for Preventing and/or Treating Tumor Lysis Syndrome
Current Pharmaceutical Design HLA-E and HLA-E-Bound Peptides: Recognition by Subsets of NK and T Cells
Current Pharmaceutical Design The Relationship Between Dietary Lipids and Serum Visfatin and Adiponectin Levels in Postmenopausal Women
Endocrine, Metabolic & Immune Disorders - Drug Targets Therapeutic Potential of Antileukotriene Drug-<i>Camellia sinensis</i> Extract Co-Formulation on Histamine Induced Asthma in Guinea Pigs
Current Drug Research Reviews Sofosbuvir: Really Meets the Unmet Needs for Hepatitis C Treatment?
Infectious Disorders - Drug Targets Review of the Currently Available Systems to Obtain Platelet Related Products to Treat Equine Musculoskeletal Injuries
Recent Patents on Regenerative Medicine Non-HLA Gene Polymorphisms and the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation
Current Stem Cell Research & Therapy Type 2 Innate Lymphoid Cells in Allergic Disease
Current Immunology Reviews (Discontinued) Growth Differentiation Factor-15 as a Biomarker of Obese Pre-diabetes and Type 2 Diabetes Mellitus in Indian Subjects: A Case-control Study
Current Diabetes Reviews Trends in Wound Repair: Cellular and Molecular Basis of Regenerative Therapy Using Electromagnetic Fields
Current Molecular Medicine Shared Signaling Pathways Between Endocrine and Immune System Receptors: The Model of Gamma Chain
Current Signal Transduction Therapy