Abstract
Although the physiological function of sleep is not completely understood, it is well documented that it contributes significantly to the process of learning and memory. Ample evidence suggests that adequate sleep is essential for fostering connections among neuronal networks for memory consolidation in the hippocampus. Sleep deprivation studies are extremely valuable in understanding why we sleep and what are the consequences of sleep loss. Experimental sleep deprivation in animals allows us to gain insight into the mechanism of sleep at levels not possible to study in human subjects. Many useful approaches have been utilized to evaluate the effect of sleep loss on cognitive function, each with relative advantages and disadvantages. In this review we discuss sleep and the detrimental effects of sleep deprivation mostly in experimental animals. The negative effects of sleep deprivation on various aspects of brain function including learning and memory, synaptic plasticity and the state of cognition-related signaling molecules are discussed.
Keywords: Modified Multiple Platform, LTP, LTD, electrophysiology, anxiety, neurogenesis, nicotine, exercise.
Current Neuropharmacology
Title:Neurobiological Consequences of Sleep Deprivation
Volume: 11 Issue: 3
Author(s): Karim Alkadhi, Munder Zagaar, Ibrahim Alhaider, Samina Salim and Abdulaziz Aleisa
Affiliation:
Keywords: Modified Multiple Platform, LTP, LTD, electrophysiology, anxiety, neurogenesis, nicotine, exercise.
Abstract: Although the physiological function of sleep is not completely understood, it is well documented that it contributes significantly to the process of learning and memory. Ample evidence suggests that adequate sleep is essential for fostering connections among neuronal networks for memory consolidation in the hippocampus. Sleep deprivation studies are extremely valuable in understanding why we sleep and what are the consequences of sleep loss. Experimental sleep deprivation in animals allows us to gain insight into the mechanism of sleep at levels not possible to study in human subjects. Many useful approaches have been utilized to evaluate the effect of sleep loss on cognitive function, each with relative advantages and disadvantages. In this review we discuss sleep and the detrimental effects of sleep deprivation mostly in experimental animals. The negative effects of sleep deprivation on various aspects of brain function including learning and memory, synaptic plasticity and the state of cognition-related signaling molecules are discussed.
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Cite this article as:
Alkadhi Karim, Zagaar Munder, Alhaider Ibrahim, Salim Samina and Aleisa Abdulaziz, Neurobiological Consequences of Sleep Deprivation, Current Neuropharmacology 2013; 11 (3) . https://dx.doi.org/10.2174/1570159X11311030001
DOI https://dx.doi.org/10.2174/1570159X11311030001 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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