Abstract
Several lympholytic and cytotoxic agents are used in acute lymphoblastic leukemia (ALL) polychemotherapy. Genetic variants for cellular components involved in the pharmacokinetics and pharmacodynamics of these drugs can influence the pharmacological response, and molecular characterization of these genetic variants could be helpful for the comprehension of the mechanisms of resistance or increased sensitivity. The purpose of this review is to carry out an update of recent publications on genes that might influence ALL treatment in terms of outcome and/or toxicity and to underlie the role of genetic variants, particularly single nucleotide polymorphisms (SNP), in predicting clinical response, with particular reference to the current protocol for ALL therapy used in Italy, AIEOP-BFM ALL 2009.
Keywords: Acute lymphoblastic leukemia, chemotherapy, pharmacogenetics.
Current Medicinal Chemistry
Title:Pharmacogenomic Approaches for Tailored Anti-Leukemic Therapy in Children
Volume: 20 Issue: 17
Author(s): G. Stocco, R. Franca, F. Verzegnassi, M. Londero, M. Rabusin and G. Decorti
Affiliation:
Keywords: Acute lymphoblastic leukemia, chemotherapy, pharmacogenetics.
Abstract: Several lympholytic and cytotoxic agents are used in acute lymphoblastic leukemia (ALL) polychemotherapy. Genetic variants for cellular components involved in the pharmacokinetics and pharmacodynamics of these drugs can influence the pharmacological response, and molecular characterization of these genetic variants could be helpful for the comprehension of the mechanisms of resistance or increased sensitivity. The purpose of this review is to carry out an update of recent publications on genes that might influence ALL treatment in terms of outcome and/or toxicity and to underlie the role of genetic variants, particularly single nucleotide polymorphisms (SNP), in predicting clinical response, with particular reference to the current protocol for ALL therapy used in Italy, AIEOP-BFM ALL 2009.
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Stocco G., Franca R., Verzegnassi F., Londero M., Rabusin M. and Decorti G., Pharmacogenomic Approaches for Tailored Anti-Leukemic Therapy in Children, Current Medicinal Chemistry 2013; 20 (17) . https://dx.doi.org/10.2174/0929867311320170008
DOI https://dx.doi.org/10.2174/0929867311320170008 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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