La(NO₃)₃.6H₂O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines

Title:La(NO₃)₃.6H₂O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines

Volume: 10 Issue: 3

Author(s): Mir Rasul Mousavi, Jasem Aboonajmi, Malek Taher Maghsoodlou, Nourallah Hazeri, Sayyed Mostafa Habibi-Khorassani and Mohyeddin Safarzaei

Affiliation:

Keywords: Lanthanum nitrate hexahydrate, piperidine, one-pot, multicomponent

Abstract: La(NO₃)₃.6H₂O was used as an efficient catalyst for highly diastereoselective synthesis of functionalized piperidines by one-pot five-component reactions of anilines and aromatic aldehydes with acetoacetic esters. This strategy proceeds by way of the Knoevenagel reaction followed by inter-molecular aza-Diels-Alder reaction. The main features of the current method comprise mild reaction conditions, easy work-up, eco-friendliness, high atom economy, short times and the products were isolated with high yields.

Cite this article as:

Rasul Mousavi Mir, Aboonajmi Jasem, Taher Maghsoodlou Malek, Hazeri Nourallah, Mostafa Habibi-Khorassani Sayyed and Safarzaei Mohyeddin, La(NO₃)₃.6H₂O Catalyzed One-pot Highly Diastereoselective Synthesis of Functionalized Piperidines, Letters in Organic Chemistry 2013; 10 (3) . https://dx.doi.org/10.2174/1570178611310030005