Abstract
Phytoestrogens are the most important therapeutic molecules that are richly present in soya based foods. Genistein (GEN) is one among the prominent constituent of soybean. Isolated form of Genistein has poor bioavailability because of its low aqueous solubility, absorption and limited clinical efficacy. Encapsulated GEN could be used for colloidal drug delivery for the treatment of diseases including breast cancer. In the present study we have prepared poly lactic acid based nanoparticles with Genistein by emulsion diffusion method. The obtained genistein-loaded nanoparticles (GEN-PLA-NPs) were characterized for their size (PCS/ Zetasizer), shape (SEM) and other physical properties using FTIR and DSC. Encapsulation efficiency, release characteristics The sizes of the particles were ranged between 100 nm and 380 nm due to different solvents that were used during the preparation of nanoparticles. Under optimal conditions, different sizes of the particles (259.7 nm, 122.3 nm and 105.7 nm) were formed with encapsulation efficiency (73.9%, 57.9% and 61.4%, respectively). The drug and polymer interaction studies were performed by FTIR and DSC. When percent release of encapsulated drug was studies in PBS (pH 7.4), it was found to be biphasic pattern (Korsmeyer-Peppas model) with 21.27% release at 37°C in 24 h. In hemolysis experiment, Genistein loaded poly (lactic acid) nanoparticles exhibited non-toxic nature. These results demonstrated the feasibility of encapsulation of GEN and its non-toxic in vitro studies.
Keywords: Phytoestrogen, sonication, crystallization, Fickian diffusion, hemolysis.
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