Abstract
Recently, the combining of different drugs has greatly improved response and survival rates in gynecological malignancies. Results are however far from being satisfactory. Treatments used in case of advanced or recurrent disease offer limited results in terms of long-term responses. The urgent need for new and more effective treatments has prompted researchers to investigate and propose new therapeutic strategies. One of the most interesting approaches that are being explored is constituted by immunotherapy. Currently, immunotherapeutic strategies include vaccination with peptide, viral vectors, carbohydrates and antiidiotypic antibodies. In addition, cell based immunotherapy has been adopted in vitro activated lymphocytes and dendritic cells. Most experience has been acquired in ovarian cancer and cervical cancer. Little has been investigated in endometrial and rare gynecologic neoplasms.
The clinical experiences and results achieved with immunotherapy in this setting of patients have been reviewed and the future avenues that are currently being explored have also been discussed.
Keywords: Anti-idiotypic antibody, cancer vaccine, cervical cancer, dendritic cells, gynecological cancer, immunotherapy, lymphocytes, ovarian cancer
Current Molecular Medicine
Title:Past, Present and Future Strategies of Immunotherapy in Gynecological Malignancies
Volume: 13 Issue: 4
Author(s): F. Bellati, C. Napoletano, I. Ruscito, V. Visconti, M. Antonilli, M.L. Gasparri, I.G. Zizzari, H. Rahimi, I. Palaia, A. Rughetti, P. Benedetti Panici and M. Nuti
Affiliation:
Keywords: Anti-idiotypic antibody, cancer vaccine, cervical cancer, dendritic cells, gynecological cancer, immunotherapy, lymphocytes, ovarian cancer
Abstract: Recently, the combining of different drugs has greatly improved response and survival rates in gynecological malignancies. Results are however far from being satisfactory. Treatments used in case of advanced or recurrent disease offer limited results in terms of long-term responses. The urgent need for new and more effective treatments has prompted researchers to investigate and propose new therapeutic strategies. One of the most interesting approaches that are being explored is constituted by immunotherapy. Currently, immunotherapeutic strategies include vaccination with peptide, viral vectors, carbohydrates and antiidiotypic antibodies. In addition, cell based immunotherapy has been adopted in vitro activated lymphocytes and dendritic cells. Most experience has been acquired in ovarian cancer and cervical cancer. Little has been investigated in endometrial and rare gynecologic neoplasms.
The clinical experiences and results achieved with immunotherapy in this setting of patients have been reviewed and the future avenues that are currently being explored have also been discussed.
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Bellati F., Napoletano C., Ruscito I., Visconti V., Antonilli M., Gasparri M.L., Zizzari I.G., Rahimi H., Palaia I., Rughetti A., Benedetti Panici P. and Nuti M., Past, Present and Future Strategies of Immunotherapy in Gynecological Malignancies, Current Molecular Medicine 2013; 13 (4) . https://dx.doi.org/10.2174/1566524011313040014
DOI https://dx.doi.org/10.2174/1566524011313040014 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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