Abstract
In this review, we are going to demonstrate the recent progresses in inorganic nanomaterial-based nanomedicines and their labeling for effective biological imaging. Nanomaterials which are classified according to their dimensionality, from zero- to three-dimensions can be utilized as nanomedicines including drug delivery, therapy and diagnosis. In the following section, the labeling of nanomaterials with various contrasting agents are introduced. Various labeling agents like fluorescence, quantum dots, upconversion nanoparticles, magnetic particles and radioisotopes can be tagged on nanomaterials for effective imaging such as optical, magnetic resonance, computed tomography, positron emission tomography and etc. The labeling of contrasting agent on nanomedicine can be summarized into intercalation, surface modification, embedment and combination depending on how and where the label is tagged. Through these approaches, multimodal biological imaging and multifunctional nanomedicine could be suggested.
Keywords: Inorganic nanomedicine, therapy, drug delivery, diagnosis, labeling, contrasting agent, biological imaging.
Current Topics in Medicinal Chemistry
Title:Inorganic Nanomedicines and their Labeling for Biological Imaging
Volume: 13 Issue: 4
Author(s): Kyoung-Min Kim, Joo-Hee Kang, Ajayan Vinu, Jin-Ho Choy and Jae-Min Oh
Affiliation:
Keywords: Inorganic nanomedicine, therapy, drug delivery, diagnosis, labeling, contrasting agent, biological imaging.
Abstract: In this review, we are going to demonstrate the recent progresses in inorganic nanomaterial-based nanomedicines and their labeling for effective biological imaging. Nanomaterials which are classified according to their dimensionality, from zero- to three-dimensions can be utilized as nanomedicines including drug delivery, therapy and diagnosis. In the following section, the labeling of nanomaterials with various contrasting agents are introduced. Various labeling agents like fluorescence, quantum dots, upconversion nanoparticles, magnetic particles and radioisotopes can be tagged on nanomaterials for effective imaging such as optical, magnetic resonance, computed tomography, positron emission tomography and etc. The labeling of contrasting agent on nanomedicine can be summarized into intercalation, surface modification, embedment and combination depending on how and where the label is tagged. Through these approaches, multimodal biological imaging and multifunctional nanomedicine could be suggested.
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Cite this article as:
Kim Kyoung-Min, Kang Joo-Hee, Vinu Ajayan, Choy Jin-Ho and Oh Jae-Min, Inorganic Nanomedicines and their Labeling for Biological Imaging, Current Topics in Medicinal Chemistry 2013; 13 (4) . https://dx.doi.org/10.2174/1568026611313040009
DOI https://dx.doi.org/10.2174/1568026611313040009 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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