Abstract
Transient Receptor Potential (TRP) proteins constitute a family of cation channels with very diverse permeation and gating properties. Likewise they have a very diverse role in mammalian physiology ranging from sensory nerve endings, the cardiac muscle to immune cells. Increasing evidence has implicated TRP channels in the pathology of diabetes, both on the level of insulin release from the pancreatic ß cells and in secondary conditions such as diabetic neuropathy, nephropathy and vasculopathy. In this review we summarize these recent findings, which all together indicate that TRP channels are interesting drug targets for the treatment of patients suffering from diabetes.
Keywords: Ion channels, diabetes, pancreatic beta cells, insulin, transient receptor potential channels
Current Topics in Medicinal Chemistry
Title:Transient Receptor Potential (TRP) Cation Channels in Diabetes
Volume: 13 Issue: 3
Author(s): Barbara Colsoul, Bernd Nilius and Rudi Vennekens
Affiliation:
Keywords: Ion channels, diabetes, pancreatic beta cells, insulin, transient receptor potential channels
Abstract: Transient Receptor Potential (TRP) proteins constitute a family of cation channels with very diverse permeation and gating properties. Likewise they have a very diverse role in mammalian physiology ranging from sensory nerve endings, the cardiac muscle to immune cells. Increasing evidence has implicated TRP channels in the pathology of diabetes, both on the level of insulin release from the pancreatic ß cells and in secondary conditions such as diabetic neuropathy, nephropathy and vasculopathy. In this review we summarize these recent findings, which all together indicate that TRP channels are interesting drug targets for the treatment of patients suffering from diabetes.
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Cite this article as:
Colsoul Barbara, Nilius Bernd and Vennekens Rudi, Transient Receptor Potential (TRP) Cation Channels in Diabetes, Current Topics in Medicinal Chemistry 2013; 13 (3) . https://dx.doi.org/10.2174/1568026611313030004
DOI https://dx.doi.org/10.2174/1568026611313030004 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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