Evolving Therapeutic Targets in Ischemic Stroke: A Concise Review

Sinoy      Sugunan; Diya      Binoy Joseph; G.      K. Rajanikant

Abstract

Ischemic stroke is the leading cause of mortality and morbidity worldwide for which the assemblage of therapeutic interventions has remained outstandingly limited. Several new insights into the causes of neuronal death during ischemic event have led to the identification of some important novel targets for intervention. This article highlights some of the promising protein targets, which are in the validation process and have the potential to get translated into viable neurotherapeutics against ischemic stroke.

Keywords: Ischemic stroke, therapeutic targets, excitotoxicity, NADPH oxidase, inflammation, MHC-I, neuroplasticity

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