Abstract
2'-Deoxy-methanocarba nucleosides are a class of compounds with important antiviral and antitumor activities. (N)-2'-deoxymethanocarbathymidine, (N)-MCT, is known as active and specific agent against herpes simplex viruses (HSV1 and 2) and Kaposi's sarcoma- associated herpes virus (KSHV). Some analogues such MRS2500 and MRS2279 have potent antithrombotic therapeutic effect due to their interactions with the purinergic P2Y1 receptors as antagonists, which have led to the new drug concepts. In the present review for the first time is provided a whole overview of the reported several synthetic approaches to the different analogues of 2'-deoxymethanocarba nucleosides as well as their biological activity.
Keywords: (N)-MCT, total synthesis, conformationally restricted nucleosides, antiviral, antitumor activities
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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