Abstract
The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species (e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progress of selected quinolines through pre-clinical development and phase I/II trials, and the lead quinoline drugs sitamaquinine and Imiquimod, are discussed in conjunction with delivery systems and combination therapies.
Keywords: Leishmaniasis, quinolines, affordable chemotherapies
Mini-Reviews in Medicinal Chemistry
Title:Quinolines as Chemotherapeutic Agents for Leishmaniasis
Volume: 13 Issue: 5
Author(s): Kristie A. Reynolds, Wendy A. Loughlin and David J. Young
Affiliation:
Keywords: Leishmaniasis, quinolines, affordable chemotherapies
Abstract: The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species (e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progress of selected quinolines through pre-clinical development and phase I/II trials, and the lead quinoline drugs sitamaquinine and Imiquimod, are discussed in conjunction with delivery systems and combination therapies.
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Cite this article as:
A. Reynolds Kristie, A. Loughlin Wendy and J. Young David, Quinolines as Chemotherapeutic Agents for Leishmaniasis, Mini-Reviews in Medicinal Chemistry 2013; 13 (5) . https://dx.doi.org/10.2174/1389557511313050010
DOI https://dx.doi.org/10.2174/1389557511313050010 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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