Abstract
Despite recent advances in our understanding of the biological basis of prostate cancer, the management of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway is increasingly implicated in a number of malignancies, including prostate carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the therapeutic implications of targeting it.
Keywords: Androgen receptor, mammalian target of rapamycin, phosphatidylinositol 3-kinase, prostate cancer, PTEN.
Current Cancer Drug Targets
Title:The PI3 Kinase Signaling Pathway in Prostate Cancer
Volume: 13 Issue: 2
Author(s): Aymen A. Elfiky and Zhenyang Jiang
Affiliation:
Keywords: Androgen receptor, mammalian target of rapamycin, phosphatidylinositol 3-kinase, prostate cancer, PTEN.
Abstract: Despite recent advances in our understanding of the biological basis of prostate cancer, the management of the disease, especially in the castration-resistant phase, remains a significant challenge. Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway is increasingly implicated in a number of malignancies, including prostate carcinogenesis. In this review, we detail the role of this pathway in the pathogenesis of prostate cancer and the therapeutic implications of targeting it.
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Cite this article as:
A. Elfiky Aymen and Jiang Zhenyang, The PI3 Kinase Signaling Pathway in Prostate Cancer, Current Cancer Drug Targets 2013; 13 (2) . https://dx.doi.org/10.2174/1568009611313020005
DOI https://dx.doi.org/10.2174/1568009611313020005 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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