Abstract
In view of the large libraries of acetylcholinesterase inhibitors (AChEIs) that are now being handled in organic synthesis, the identification of drug biological activity is advisable prior to synthesis and this can be achieved by employing predictive biological property methods. In this sense, Quantitative Structure–Activity Relationships (QSAR) or docking approaches have emerged as promising tools. The intention of this review is to summarize the present knowledge concerning computational predictions of AChEIs and AChE.
Keywords: Acetylcholinesterase inhibitors, computational predictions, docking approaches, molecular modeling, QSAR
Central Nervous System Agents in Medicinal Chemistry
Title:Acetylcholinesterase Inhibitors from QSAR Point of View: How Close are We?
Volume: 13 Issue: 1
Author(s): Anuradha Sharma and Poonam Piplani
Affiliation:
Keywords: Acetylcholinesterase inhibitors, computational predictions, docking approaches, molecular modeling, QSAR
Abstract: In view of the large libraries of acetylcholinesterase inhibitors (AChEIs) that are now being handled in organic synthesis, the identification of drug biological activity is advisable prior to synthesis and this can be achieved by employing predictive biological property methods. In this sense, Quantitative Structure–Activity Relationships (QSAR) or docking approaches have emerged as promising tools. The intention of this review is to summarize the present knowledge concerning computational predictions of AChEIs and AChE.
Export Options
About this article
Cite this article as:
Sharma Anuradha and Piplani Poonam, Acetylcholinesterase Inhibitors from QSAR Point of View: How Close are We?, Central Nervous System Agents in Medicinal Chemistry 2013; 13 (1) . https://dx.doi.org/10.2174/1871524911313010009
DOI https://dx.doi.org/10.2174/1871524911313010009 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Role of FAS in HIV Infection
Current HIV Research Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy
CNS & Neurological Disorders - Drug Targets The Function and Integrity of the Neurovascular Unit Rests Upon the Integration of the Vascular and Inflammatory Cell Systems
Current Neurovascular Research Peripheral Mononuclear Cell Rejuvenation for Senescence Surveillance in Alzheimer Disease
Current Pharmaceutical Design Obesity and Pregnancy
Current Women`s Health Reviews Vitamin D and Cardio-Metabolic Risk Factors in Overweight Adults: An Overview of the Evidence
Current Pharmaceutical Design Charge Deficient Analogues of the Natural Polyamines
Current Pharmaceutical Design Therapy Stratifications and Novel Approach in Pursuit of Aids Related Kaposi’s Sarcoma Management- A paradigm for Non Invasiveness
Current Drug Delivery The Role of Fatty Acids in the Regulation of Cerebral Vascular Function and Neuroprotection in Ischemia
CNS & Neurological Disorders - Drug Targets Enhanced Tolerance against Early and Late Apoptotic Oxidative Stress in Mammalian Neurons through Nicotinamidase and Sirtuin Mediated Pathways
Current Neurovascular Research Biomarkers in Post-stroke Depression
Current Neurovascular Research Gestational Exposure to Serotonin Reuptake Inhibitors and Pregnancy Outcome; Exploring the Role of Bias and Confounders
Current Neuropharmacology The Effects of Maternally Administered Methadone, Buprenorphine and Naltrexone on Offspring: Review of Human and Animal Data
Current Neuropharmacology The Effect of Alcohol on Gastrointestinal Motility
Reviews on Recent Clinical Trials Patent Selections:
Recent Patents on CNS Drug Discovery (Discontinued) Cyclooxygenases Regulation by Estradiol on Endothelium
Current Pharmaceutical Design 1,8-Naphthyridine derivatives as Cholinesterases Inhibitors and Cell Ca2+ Regulators, a Multitarget Strategy for Alzheimer's Disease
Current Topics in Medicinal Chemistry Preterm Infant Swallowing and Respiration Coordination During Oral Feeding: Relationship to Dysphagia and Aspiration
Current Pediatric Reviews Membrane Interactions of Oligomeric Alpha-Synuclein: Potential Role in Parkinsons Disease
Current Protein & Peptide Science The Wnt Pathway in Mood Disorders
Current Neuropharmacology