Abstract
Standardization is of great importance to ascertain the botanical identity and quality of herbal drugs. Among the various analytical tools available, HPLC is one of the major tools for the herbal drug standardization. Adhatoda vasica Nees is well known shrub described in Ayurveda particularly for the treatment of respiratory ailments. The potential of the plant as bronchodilator and antitussive is mainly attributed to the presence of pyrrolo [2,1-b] quinazoline alkaloids. In the present study, seasonal variation of the vasicine and deoxyvasicinone in roots and leaves of Adhatoda vasica has been investigated. Maximum amount of vasicine was found in the month of August in both leaves and roots whereas Deoxyvasicinone was found to be maximum in month of December- January in roots and in November for leaves. Vasicine and Deoxyvasicinone were present in higher amounts in leaves as compared to roots. The quantitative estimation of the alkaloids was done by HPLC.
Keywords: Seasonal variation, alkaloids, roots, leaves, isolation, standardization
The Natural Products Journal
Title:Estimation of Seasonal Variation of Two Major Pyrrolo [2,1-b] Quinazoline Alkaloids of Adhatoda vasica by HPLC
Volume: 3 Issue: 1
Author(s): Sandeep Patil, Ritu Ojha, Gurpreet Kaur, Kunal Nepali, Shilpi Aggarwal and Kanaya Lal Dhar
Affiliation:
Keywords: Seasonal variation, alkaloids, roots, leaves, isolation, standardization
Abstract: Standardization is of great importance to ascertain the botanical identity and quality of herbal drugs. Among the various analytical tools available, HPLC is one of the major tools for the herbal drug standardization. Adhatoda vasica Nees is well known shrub described in Ayurveda particularly for the treatment of respiratory ailments. The potential of the plant as bronchodilator and antitussive is mainly attributed to the presence of pyrrolo [2,1-b] quinazoline alkaloids. In the present study, seasonal variation of the vasicine and deoxyvasicinone in roots and leaves of Adhatoda vasica has been investigated. Maximum amount of vasicine was found in the month of August in both leaves and roots whereas Deoxyvasicinone was found to be maximum in month of December- January in roots and in November for leaves. Vasicine and Deoxyvasicinone were present in higher amounts in leaves as compared to roots. The quantitative estimation of the alkaloids was done by HPLC.
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Cite this article as:
Patil Sandeep, Ojha Ritu, Kaur Gurpreet, Nepali Kunal, Aggarwal Shilpi and Lal Dhar Kanaya, Estimation of Seasonal Variation of Two Major Pyrrolo [2,1-b] Quinazoline Alkaloids of Adhatoda vasica by HPLC, The Natural Products Journal 2013; 3 (1) . https://dx.doi.org/10.2174/2210315511303010007
DOI https://dx.doi.org/10.2174/2210315511303010007 |
Print ISSN 2210-3155 |
Publisher Name Bentham Science Publisher |
Online ISSN 2210-3163 |
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