Abstract
Age represents a significant risk factor for the onset and progression of cardiovascular disease, with the increase in life expectancy in developed countries going in parallel with increased incidence of such pathologies. Treatment strategies alternative or additive to pharmacological treatments are needed. The relationship between aging and progenitor cell-mediated repair is of great interest. Endothelial progenitor cells (EPC) mediate repair mechanisms for endothelial regeneration and maintenance, but they are subject to ageassociated changes affecting negatively their number and/or function.
Aim of this review is to examine the impact of age on EPC-mediated vascular repair, with a focus on the metabolic pathways involved and on the therapeutic targets with potential for attenuating this effect.
Keywords: Aging, senescence, vascular disease, endothelial progenitor cells, metabolic pathways, repair mechanisms, vascular repair, endothelial regeneration, pathologies, therapeutic targets
Current Pharmaceutical Design
Title:Effect of Aging on Metabolic Pathways in Endothelial Progenitor Cells
Volume: 19 Issue: 13
Author(s): Francesca Felice, Maria Chiara Barsotti, Pavel Poredos, Alberto Balbarini and Rossella Di Stefano
Affiliation:
Keywords: Aging, senescence, vascular disease, endothelial progenitor cells, metabolic pathways, repair mechanisms, vascular repair, endothelial regeneration, pathologies, therapeutic targets
Abstract: Age represents a significant risk factor for the onset and progression of cardiovascular disease, with the increase in life expectancy in developed countries going in parallel with increased incidence of such pathologies. Treatment strategies alternative or additive to pharmacological treatments are needed. The relationship between aging and progenitor cell-mediated repair is of great interest. Endothelial progenitor cells (EPC) mediate repair mechanisms for endothelial regeneration and maintenance, but they are subject to ageassociated changes affecting negatively their number and/or function.
Aim of this review is to examine the impact of age on EPC-mediated vascular repair, with a focus on the metabolic pathways involved and on the therapeutic targets with potential for attenuating this effect.
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Cite this article as:
Felice Francesca, Chiara Barsotti Maria, Poredos Pavel, Balbarini Alberto and Di Stefano Rossella, Effect of Aging on Metabolic Pathways in Endothelial Progenitor Cells, Current Pharmaceutical Design 2013; 19 (13) . https://dx.doi.org/10.2174/1381612811319130003
DOI https://dx.doi.org/10.2174/1381612811319130003 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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