Abstract
The purpose of this study was to investigate how a viral infection affecting the epithelial cells could be influenced by the presence of the opportunistic Staphylococcus aureus soluble mediators. The viral antigens presence, apoptosis and cytokine profiles of HeLa cells infected with HSV-1 and pre-/postreated with different bacterial soluble fractions were evaluated. Soluble bacterial molecules could modulate HeLa cells functions to prevent the development of viral infection, but later stages of viral infection are less affected by bacterial soluble mediators. The in vitro cooperative action of HSV-1 and of S. aureus soluble fractions modulated the immune response of the infected HeLa cells, mainly by triggering the release of pro-inflammatory cytokines.
Keywords: HSV, S. aureus, Co-infection
Current Organic Chemistry
Title:Modulation of Interaction Between Virus and Eukaryotic Host by Exposure to S. aureus Bacterial Soluble Fractions
Volume: 17 Issue: 2
Author(s): Coralia Bleotu, Gratiela Pircalabioru, Roxana Dragusel, Ioana-Madalina Aldea, Botezatu Anca, Otilia Banu, Grigore Mihaescu, Costin Eugen Cernescu and Carmen Cristina Diaconu
Affiliation:
Keywords: HSV, S. aureus, Co-infection
Abstract: The purpose of this study was to investigate how a viral infection affecting the epithelial cells could be influenced by the presence of the opportunistic Staphylococcus aureus soluble mediators. The viral antigens presence, apoptosis and cytokine profiles of HeLa cells infected with HSV-1 and pre-/postreated with different bacterial soluble fractions were evaluated. Soluble bacterial molecules could modulate HeLa cells functions to prevent the development of viral infection, but later stages of viral infection are less affected by bacterial soluble mediators. The in vitro cooperative action of HSV-1 and of S. aureus soluble fractions modulated the immune response of the infected HeLa cells, mainly by triggering the release of pro-inflammatory cytokines.
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Bleotu Coralia, Pircalabioru Gratiela, Dragusel Roxana, Aldea Ioana-Madalina, Anca Botezatu, Banu Otilia, Mihaescu Grigore, Eugen Cernescu Costin and Cristina Diaconu Carmen, Modulation of Interaction Between Virus and Eukaryotic Host by Exposure to S. aureus Bacterial Soluble Fractions, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020009
DOI https://dx.doi.org/10.2174/1385272811317020009 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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