Abstract
Interaction of the single-stranded DNA (ssDNA) aptamers and proteins was investigated on graphene oxide (GO)-based biosensors. GO was applied for biological applications because of its unique properties, which include water dispensability, exclusive selection of ssDNA, and fluorescence-quenching effects. In this study, aptamer-functionalized GO sheets of nanometer-scale thickness and micrometer-scale dimension were developed. Based on a simple mixed-and-measured strategy, platelet-derived growth factors (PDGF), the tumor marker of ovarian cancer, triggered aptamers conformation switched and deliberated aptamers from GO surface according to thermal dynamic analysis. By functionalizing with various aptamers on GO, the strategy could provide designed functions on GO-based biosensors, bioreactors, and other devices.
Keywords: Aptamers, Biosensors, Functionalization, Graphene oxide, Platelet-derived growth factors, Tumor marker
Current Organic Chemistry
Title:Tumor Marker Detection by Aptamer-Functionalized Graphene Oxide
Volume: 17 Issue: 2
Author(s): Ming-Yu Lin, Yen-Pei Lu, Alexandru M. Grumezescu, Fu H. Ho, Ying-Hsien Kao, Yuh-Shyong Yang and Chih-Hui Yang
Affiliation:
Keywords: Aptamers, Biosensors, Functionalization, Graphene oxide, Platelet-derived growth factors, Tumor marker
Abstract: Interaction of the single-stranded DNA (ssDNA) aptamers and proteins was investigated on graphene oxide (GO)-based biosensors. GO was applied for biological applications because of its unique properties, which include water dispensability, exclusive selection of ssDNA, and fluorescence-quenching effects. In this study, aptamer-functionalized GO sheets of nanometer-scale thickness and micrometer-scale dimension were developed. Based on a simple mixed-and-measured strategy, platelet-derived growth factors (PDGF), the tumor marker of ovarian cancer, triggered aptamers conformation switched and deliberated aptamers from GO surface according to thermal dynamic analysis. By functionalizing with various aptamers on GO, the strategy could provide designed functions on GO-based biosensors, bioreactors, and other devices.
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Cite this article as:
Lin Ming-Yu, Lu Yen-Pei, Grumezescu M. Alexandru, Ho H. Fu, Kao Ying-Hsien, Yang Yuh-Shyong and Yang Chih-Hui, Tumor Marker Detection by Aptamer-Functionalized Graphene Oxide, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020008
DOI https://dx.doi.org/10.2174/1385272811317020008 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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