Abstract
Staphylococcus (S.) aureus is a versatile human pathogen responsible for both nosocomial and community acquired infections. The ability of this opportunistic pathogen to cause a large spectrum of infections is due to an impressive spectrum of virulence determinants. The coordinated expression of many virulence determinants during the infectious process is regulated by the agr quorum-sensing system (QS). Different studies have shown that agr mutants are less virulent comparatively with their wild counterparts. Thus, the inhibition of quorum sensing genes expression may represent a new strategy of virulence and pathogenicity attenuation of S. aureus clinical strains. The aim of this paper was to review the main types of S. aureus quorum sensing inhibitors (QSI) known until present, focusing on a new strategy of virulence attenuation based on probiotics. It was demonstrated by real-time RT-qPCR that the soluble factors accumulated in the probiotic cultures are inhibiting the QS agr genes expression in S. aureus clinical strains, representing thus an interesting, new anti-microbial strategy for the prevention and therapy of staphylococcal infections.
Keywords: Staphylococcus aureus, Quorum-sensing inhibitors, Antipathogenic strategy, Probiotic
Current Organic Chemistry
Title:Current Solutions for the Interception of Quorum Sensing in Staphylococcus aureus
Volume: 17 Issue: 2
Author(s): Ani Ioana Cotar, Bogdan Ionescu, Diana Pelinescu, Chrissa Voidarou, Veronica Lazar, Eugenia Bezirtzoglou and Mariana Carmen Chifiriuc
Affiliation:
Keywords: Staphylococcus aureus, Quorum-sensing inhibitors, Antipathogenic strategy, Probiotic
Abstract: Staphylococcus (S.) aureus is a versatile human pathogen responsible for both nosocomial and community acquired infections. The ability of this opportunistic pathogen to cause a large spectrum of infections is due to an impressive spectrum of virulence determinants. The coordinated expression of many virulence determinants during the infectious process is regulated by the agr quorum-sensing system (QS). Different studies have shown that agr mutants are less virulent comparatively with their wild counterparts. Thus, the inhibition of quorum sensing genes expression may represent a new strategy of virulence and pathogenicity attenuation of S. aureus clinical strains. The aim of this paper was to review the main types of S. aureus quorum sensing inhibitors (QSI) known until present, focusing on a new strategy of virulence attenuation based on probiotics. It was demonstrated by real-time RT-qPCR that the soluble factors accumulated in the probiotic cultures are inhibiting the QS agr genes expression in S. aureus clinical strains, representing thus an interesting, new anti-microbial strategy for the prevention and therapy of staphylococcal infections.
Export Options
About this article
Cite this article as:
Ioana Cotar Ani, Ionescu Bogdan, Pelinescu Diana, Voidarou Chrissa, Lazar Veronica, Bezirtzoglou Eugenia and Carmen Chifiriuc Mariana, Current Solutions for the Interception of Quorum Sensing in Staphylococcus aureus, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020004
DOI https://dx.doi.org/10.2174/1385272811317020004 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Need for Diagnostic Criteria in Systemic Vasculitis
Current Immunology Reviews (Discontinued) Bacteremic Streptococcus pneumoniae in Community-Acquired Pneumonia: An Update
Current Respiratory Medicine Reviews Short Term Statin Treatment Improves Survival and Differentially Regulates Macrophage-Mediated Responses to Staphylococcus aureus
Current Pharmaceutical Biotechnology The Adult Patient with Eisenmenger Syndrome: A Medical Update after Dana Point Part III: Specific Management and Surgical Aspects
Current Cardiology Reviews Chemistry and Pharmacology of Natural Catechins from <i>Camellia sinensis</i> as Anti-MRSA Agents
Current Topics in Medicinal Chemistry Cardiovascular Diseases in Pregnancy - A Brief Overview
Current Cardiology Reviews Additive Effect of MCP in Combination with Cefotaxime Against Staphylococcus aureus
Medicinal Chemistry Intracellular Life of Coxiella burnetii in Macrophages: Insight into Q Fever Immunopathology
Current Immunology Reviews (Discontinued) Reviewing the Cardiovascular Complications of HIV Infection After the Introduction of Highly Active Antiretroviral Therapy
Current Drug Targets - Cardiovascular & Hematological Disorders Linezolid in Children: Recent Patents and Advances
Recent Patents on Anti-Infective Drug Discovery New Antibiotics for Severe ICU-Aquired Bacterial Infections
Infectious Disorders - Drug Targets Severe Community-Acquired Pneumonia (CAP) due to Atypical Pathogens
Current Respiratory Medicine Reviews Catheter Related Line Sepsis Resulting from Mycobacterium <i>chelonae</i> Infection in an Immunocompromised Host
Infectious Disorders - Drug Targets Current Evidence on the Evaluation and Management of Fever Without a Source in Infants Aged 0-90 Days: A Review
Reviews on Recent Clinical Trials Anionic Antimicrobial Peptides from Eukaryotic Organisms and their Mechanisms of Action
Current Chemical Biology A Review of Selected Adult Congenital Heart Diseases Encountered in Daily Practice
Current Cardiology Reviews Phytochemicals as Inhibitors of Candida Biofilm
Current Pharmaceutical Design Strategies for Antimicrobial Drug Delivery to Biofilm
Current Pharmaceutical Design Inflammatory Syndrome in Chronic Kidney Disease: Pathogenesis and Influence on Outcomes
Inflammation & Allergy - Drug Targets (Discontinued) Infective Endocarditis Complicating Hypertrophic Obstructive Cardiomyopathy: Is Antibiotic Prophylaxis Really Unnecessary?
Current Cardiology Reviews