Abstract
Staphylococcus (S.) aureus is a versatile human pathogen responsible for both nosocomial and community acquired infections. The ability of this opportunistic pathogen to cause a large spectrum of infections is due to an impressive spectrum of virulence determinants. The coordinated expression of many virulence determinants during the infectious process is regulated by the agr quorum-sensing system (QS). Different studies have shown that agr mutants are less virulent comparatively with their wild counterparts. Thus, the inhibition of quorum sensing genes expression may represent a new strategy of virulence and pathogenicity attenuation of S. aureus clinical strains. The aim of this paper was to review the main types of S. aureus quorum sensing inhibitors (QSI) known until present, focusing on a new strategy of virulence attenuation based on probiotics. It was demonstrated by real-time RT-qPCR that the soluble factors accumulated in the probiotic cultures are inhibiting the QS agr genes expression in S. aureus clinical strains, representing thus an interesting, new anti-microbial strategy for the prevention and therapy of staphylococcal infections.
Keywords: Staphylococcus aureus, Quorum-sensing inhibitors, Antipathogenic strategy, Probiotic
Current Organic Chemistry
Title:Current Solutions for the Interception of Quorum Sensing in Staphylococcus aureus
Volume: 17 Issue: 2
Author(s): Ani Ioana Cotar, Bogdan Ionescu, Diana Pelinescu, Chrissa Voidarou, Veronica Lazar, Eugenia Bezirtzoglou and Mariana Carmen Chifiriuc
Affiliation:
Keywords: Staphylococcus aureus, Quorum-sensing inhibitors, Antipathogenic strategy, Probiotic
Abstract: Staphylococcus (S.) aureus is a versatile human pathogen responsible for both nosocomial and community acquired infections. The ability of this opportunistic pathogen to cause a large spectrum of infections is due to an impressive spectrum of virulence determinants. The coordinated expression of many virulence determinants during the infectious process is regulated by the agr quorum-sensing system (QS). Different studies have shown that agr mutants are less virulent comparatively with their wild counterparts. Thus, the inhibition of quorum sensing genes expression may represent a new strategy of virulence and pathogenicity attenuation of S. aureus clinical strains. The aim of this paper was to review the main types of S. aureus quorum sensing inhibitors (QSI) known until present, focusing on a new strategy of virulence attenuation based on probiotics. It was demonstrated by real-time RT-qPCR that the soluble factors accumulated in the probiotic cultures are inhibiting the QS agr genes expression in S. aureus clinical strains, representing thus an interesting, new anti-microbial strategy for the prevention and therapy of staphylococcal infections.
Export Options
About this article
Cite this article as:
Ioana Cotar Ani, Ionescu Bogdan, Pelinescu Diana, Voidarou Chrissa, Lazar Veronica, Bezirtzoglou Eugenia and Carmen Chifiriuc Mariana, Current Solutions for the Interception of Quorum Sensing in Staphylococcus aureus, Current Organic Chemistry 2013; 17 (2) . https://dx.doi.org/10.2174/1385272811317020004
DOI https://dx.doi.org/10.2174/1385272811317020004 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
MRSA Infections: From Classical Treatment to Suicide Drugs
Current Medicinal Chemistry Non-Microbicidal Control of Bacterial Biofilms with Small Molecules
Anti-Infective Agents Prevention of Bacterial Endocarditis
Cardiovascular & Hematological Disorders-Drug Targets Natural Products Towards the Discovery of Potential Future Antithrombotic Drugs
Current Pharmaceutical Design Novel Strategies for Combating Pathogenic Biofilms Using Plant Products and Microbial Antibiosis
Current Pharmaceutical Biotechnology Rheumatoid Nodulosis in a Patient with Lupus Erythematosus: Case Report and Review
Current Rheumatology Reviews Epidemiology of Septic Acute Kidney Injury
Current Drug Targets Elucidating Protein-protein Interactions Through Computational Approaches and Designing Small Molecule Inhibitors Against them for Various Diseases
Current Topics in Medicinal Chemistry Aspirin Resistance in Cardiovascular Disease: Pathogenesis, Diagnosis and Clinical Impact
Current Pharmaceutical Design Contrast Enhanced Sonography for Diagnosis of (Peri-) Splenic Pathology
Current Medical Imaging HtrA Protease Family as Therapeutic Targets
Current Pharmaceutical Design Pre-clinical Impact of the Synergistic Mechanism of Daptomycin and Ceftaroline on Patients with Methicillin-resistant Staphylococcus aureus Bacteremia Infections
Current Reviews in Clinical and Experimental Pharmacology Is There an Association between Periodontitis and Hypertension?
Current Cardiology Reviews Endophthalmitis
Anti-Infective Agents in Medicinal Chemistry Macrolides Allergy
Current Pharmaceutical Design Juvenile Systemic Lupus Erythematosus
Current Pediatric Reviews Orchestrating HIV Neutralization by Secondary Immune Response- Mediated Induction of RF Antibodies
Current Immunology Reviews (Discontinued) DNA Microarrays - An Armory for Combating Infectious Diseases in the New Century
Infectious Disorders - Drug Targets Bacteriophages and Phage-Derived Proteins – Application Approaches
Current Medicinal Chemistry Targeting RGD Recognizing Integrins: Drug Development, Biomaterial Research, Tumor Imaging and Targeting
Current Pharmaceutical Design