Abstract
Nitrogen-containing bioactive alkaloids of plant origin play a significant role in human health and medicine. Several semisynthetic antimitotic alkaloids are successful in anticancer drug development. Gloriosa superba biosynthesizes substantial quantities of colchicine, a bioactive molecule for gout treatment. Colchicine also has antimitotic activity, preventing growth of cancer cells by interacting with microtubules, which could lead to the design of better cancer therapeutics. Further, several colchicine semisynthetics are less toxic than colchicine. Research is being conducted on effective, less toxic colchicine semisynthetic formulations with potential drug delivery strategies directly targeting multiple solid cancers. This article reviews the dynamic state of anticancer drug development from colchicine semisynthetics and natural colchicine production and briefly discusses colchicine biosynthesis.
Keywords: Bioreactor, cancer, colchicine, thiocolchicine dimers, Gloriosa superba, Colchicine Semisynthetics, Chemotherapeutics, bioactive alkaloids, plant origin, antimitotic alkaloids
Current Medicinal Chemistry
Title:Colchicine Semisynthetics: Chemotherapeutics for Cancer?
Volume: 20 Issue: 7
Author(s): G. Sivakumar
Affiliation:
Keywords: Bioreactor, cancer, colchicine, thiocolchicine dimers, Gloriosa superba, Colchicine Semisynthetics, Chemotherapeutics, bioactive alkaloids, plant origin, antimitotic alkaloids
Abstract: Nitrogen-containing bioactive alkaloids of plant origin play a significant role in human health and medicine. Several semisynthetic antimitotic alkaloids are successful in anticancer drug development. Gloriosa superba biosynthesizes substantial quantities of colchicine, a bioactive molecule for gout treatment. Colchicine also has antimitotic activity, preventing growth of cancer cells by interacting with microtubules, which could lead to the design of better cancer therapeutics. Further, several colchicine semisynthetics are less toxic than colchicine. Research is being conducted on effective, less toxic colchicine semisynthetic formulations with potential drug delivery strategies directly targeting multiple solid cancers. This article reviews the dynamic state of anticancer drug development from colchicine semisynthetics and natural colchicine production and briefly discusses colchicine biosynthesis.
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Cite this article as:
Sivakumar G., Colchicine Semisynthetics: Chemotherapeutics for Cancer?, Current Medicinal Chemistry 2013; 20 (7) . https://dx.doi.org/10.2174/0929867311320070005
DOI https://dx.doi.org/10.2174/0929867311320070005 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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