Abstract
Molecular therapy is emerging as a potential strategy for the treatment of many diseases. Correct regulation of gene expression is essential for both, to normal development and proper functioning of the all the organisms. Even after four decades of intensive research, it is still a major problem from regulatory and technical point of view, to replace defective genes. The technology of decoy oligonucleotides has received considerable attention to treat and cure a variety of diseases and abnormal physiological conditions, because they provide a rational way to design and selective regulation of a specific gene expression. Decoy oligonucleotides are widely used as inhibitors of specific gene expression because they can offer exciting possibility of expression and blocking of a particular gene without any changes in the functions of other genes. Advances in the decoy oligonucleotides are rapidly paving the way to new insights into the origin and treatment of inflammatory, cancer and/or other immune disorders. The review covers the progress achieved towards the development of decoy oligonucleotides as a potential strategy in a new class of molecular therapy.
Keywords: DNA, decoy oligonucleotide, NF-κB decoy, oligonucleotides delivery, transcription factor
Current Drug Discovery Technologies
Title:Application of Decoy Oligonucleotides as Novel Therapeutic Strategy: A Contemporary Overview
Volume: 10 Issue: 1
Author(s): Mohammad Zaki Ahmad, Sohail Akhter, Neha Mallik, Mohammad Anwar, Wajda Tabassum and Farhan Jalees Ahmad
Affiliation:
Keywords: DNA, decoy oligonucleotide, NF-κB decoy, oligonucleotides delivery, transcription factor
Abstract: Molecular therapy is emerging as a potential strategy for the treatment of many diseases. Correct regulation of gene expression is essential for both, to normal development and proper functioning of the all the organisms. Even after four decades of intensive research, it is still a major problem from regulatory and technical point of view, to replace defective genes. The technology of decoy oligonucleotides has received considerable attention to treat and cure a variety of diseases and abnormal physiological conditions, because they provide a rational way to design and selective regulation of a specific gene expression. Decoy oligonucleotides are widely used as inhibitors of specific gene expression because they can offer exciting possibility of expression and blocking of a particular gene without any changes in the functions of other genes. Advances in the decoy oligonucleotides are rapidly paving the way to new insights into the origin and treatment of inflammatory, cancer and/or other immune disorders. The review covers the progress achieved towards the development of decoy oligonucleotides as a potential strategy in a new class of molecular therapy.
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Zaki Ahmad Mohammad, Akhter Sohail, Mallik Neha, Anwar Mohammad, Tabassum Wajda and Jalees Ahmad Farhan, Application of Decoy Oligonucleotides as Novel Therapeutic Strategy: A Contemporary Overview, Current Drug Discovery Technologies 2013; 10 (1) . https://dx.doi.org/10.2174/1570163811310010009
DOI https://dx.doi.org/10.2174/1570163811310010009 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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