Abstract
The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.
Keywords: Behaviour, Dopamine, Locus Coeruleus, Methamphetamine, Neurochemistry, Norepinephrine, Substantia Nigra, Drugs of Abuse
Current Neuropharmacology
Title:The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity
Volume: 11 Issue: 1
Author(s): Michela Ferrucci, Filippo S. Giorgi, Alessia Bartalucci, Carla L. Busceti and Francesco Fornai
Affiliation:
Keywords: Behaviour, Dopamine, Locus Coeruleus, Methamphetamine, Neurochemistry, Norepinephrine, Substantia Nigra, Drugs of Abuse
Abstract: The activity of locus coeruleus (LC) neurons has been extensively investigated in a variety of behavioural states. In fact this norepinephrine (NE)-containing nucleus modulates many physiological and pathological conditions including the sleep-waking cycle, movement disorders, mood alterations, convulsive seizures, and the effects of drugs such as psychostimulants and opioids. This review focuses on the modulation exerted by central NE pathways on the behavioural and neurotoxic effects produced by the psychostimulant methamphetamine, essentially the modulation of the activity of mesencephalic dopamine (DA) neurons. In fact, although NE in itself mediates some behavioural effects induced by methamphetamine, NE modulation of DA release is pivotal for methamphetamine-induced behavioural states and neurotoxicity. These interactions are discussed on the basis of the state of the art of the functional neuroanatomy of central NE- and DA systems. Emphasis is given to those brain sites possessing a remarkable overlapping of both neurotransmitters.
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Cite this article as:
Ferrucci Michela, S. Giorgi Filippo, Bartalucci Alessia, L. Busceti Carla and Fornai Francesco, The Effects of Locus Coeruleus and Norepinephrine in Methamphetamine Toxicity, Current Neuropharmacology 2013; 11 (1) . https://dx.doi.org/10.2174/1570159X11311010010
DOI https://dx.doi.org/10.2174/1570159X11311010010 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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