Abstract
Amorphous materials have always been an essential part of pharmaceutical research They are important because of their characteristic solubility characteristics, common occurrence, and physicochemical instability relative to corresponding crystals. Some pharmaceutical agents have a tendency to exist as amorphous solids, while others require prevention of their crystallization to remain in the amorphous state in order to achieve desire characteristics. Amorphous solids can be stabilized by some common pharmaceutical processes like solid dispersion technique, solvent evaporation, milling, lipid dispersion. This article reviews the methodologies and approaches for stabilization of amorphous form.
Keywords: Amorphous solid, crystallization, dispersion techniques, milling, physicochemical instability, stabilization
Current Drug Therapy
Title:Approaches to Stabilize Amorphous Form - A Review
Volume: 7 Issue: 4
Author(s): Kisan R. Jadhav, Sharad S. Pacharane, Priti P. Pednekar, Praveen V. Koshy and Vilasrao J. Kadam
Affiliation:
Keywords: Amorphous solid, crystallization, dispersion techniques, milling, physicochemical instability, stabilization
Abstract: Amorphous materials have always been an essential part of pharmaceutical research They are important because of their characteristic solubility characteristics, common occurrence, and physicochemical instability relative to corresponding crystals. Some pharmaceutical agents have a tendency to exist as amorphous solids, while others require prevention of their crystallization to remain in the amorphous state in order to achieve desire characteristics. Amorphous solids can be stabilized by some common pharmaceutical processes like solid dispersion technique, solvent evaporation, milling, lipid dispersion. This article reviews the methodologies and approaches for stabilization of amorphous form.
Export Options
About this article
Cite this article as:
R. Jadhav Kisan, S. Pacharane Sharad, P. Pednekar Priti, V. Koshy Praveen and J. Kadam Vilasrao, Approaches to Stabilize Amorphous Form - A Review, Current Drug Therapy 2012; 7 (4) . https://dx.doi.org/10.2174/157488512804999118
DOI https://dx.doi.org/10.2174/157488512804999118 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
Call for Papers in Thematic Issues
Novel Therapeutic Approaches and Biomarkers for Chronic Kidney Disease (CKD)
The thematic issue on "Novel Therapeutic Approaches and Biomarkers for CKD" aims to provide a comprehensive exploration of cutting-edge strategies for the management of chronic kidney disease (CKD). This issue will delve into emerging therapeutic targets, focusing on critical aspects such as podocyte injury, endothelial dysfunction, and tubulointerstitial fibrosis, which ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Integration of the Glutamatergic and the White Matter Hypotheses of Schizophrenias Etiology
Current Neuropharmacology Thin Metal Films in Resistivity-based Chemical Sensing
Current Analytical Chemistry Peroxisome Proliferator-Activated Receptor Agonists as Potential Therapeutic Agents in Multiple Sclerosis
Mini-Reviews in Medicinal Chemistry The Physiology of Nitric Oxide: Control and Consequences
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents <i>Nigella sativa</i> L., Supplementary Plant with Anticholinesterase Effect for Cognition Problems: A Kinetic Study
Current Aging Science Formulation Development and Evaluation of Novel Vesicular Carrier for Enhancement of Bioavailability of Poorly Soluble Drug
Pharmaceutical Nanotechnology Commentary 1 (Research Highlights: Parkinson’s Disease and α-Synuclein: Passing it on)
CNS & Neurological Disorders - Drug Targets Neurobiology of Sleep Disturbances in Neurodegenerative Disorders
Current Pharmaceutical Design Survey of NMDA Receptor-related Biomarkers for Depression
Current Pharmaceutical Design Diagnosis and Management of Lynch Syndrome
Recent Patents on Regenerative Medicine γ-Secretase as a Therapeutic Target for Treatment of Alzheimers Disease
Current Pharmaceutical Design Considering a Potential Role of Linalool as a Mood Stabilizer for Bipolar Disorder
Current Pharmaceutical Design Synthetic Methods Applied in the Preparation of Coumarin-based Compounds
Current Organic Chemistry 1950 MHz Electromagnetic Fields Ameliorate Aβ Pathology in Alzheimer’s Disease Mice
Current Alzheimer Research Heart Failure in North America
Current Cardiology Reviews Meet Our Editorial Board Member
Current Neuropharmacology Apolipoprotein E Gene Revisited: Contribution of Rare Variants to Alzheimer’s Disease Susceptibility in Southern Chinese
Current Alzheimer Research The Impact of Small Heat Shock Proteins (HspBs) in Alzheimer’s and Other Neurological Diseases
Current Pharmaceutical Design New Tuberculosis Drugs in Development
Current Topics in Medicinal Chemistry Prevalence and Prognostic Value of Depression and Anxiety in Patients with Diabetic Foot Ulcers and Possibilities of their Treatment
Current Diabetes Reviews