Applicability and Approaches of (Meth) Acrylate Copolymers (Eudragits) in Novel Drug Delivery Systems

Kumar      Animesh; Moin      Afrasim; Rami      R. Bommareddy; Ahmed      Ayaz; Ravi      Shruthi; Hoskote      G. Shivakumar

Abstract

This review focuses on the recent developments and future trends dealing with its modifications, encompassing the different grades of polymethacrylates polymers based formulations. The last three decades of pioneering works explain it as a new functional material of high potential value in novel drug delivery. Polymethacrylates are synthetic cationic and anionic copolymers of dimethylaminoethyl methacrylates, methacrylic acid, and methacrylic acid esters in varying ratios, generating a new and modified patterned polymer due to their electrical characters and pH- dependent solubility. Based on current research and existing products, some new and futuristic approaches in this fascinating area have been thoroughly explored and discussed. These polymers are used as release retardant in different formulations like oral capsules and tablets, film-coating agents for protective purposes and provide sustained release formulations. This review also screens the current applications of these polymers in the development of microparticles, patches, nanoparticles, colon targeted formulations, ophthalmic, vaccine delivery, taste masking agent and its pivotal application in gene delivery systems. This work summarizes the achievements of past which can be extrapolated to characterize the possible array of polymeric interactions, exploiting their desirable properties for future studies.

Keywords: Applications, polymethacrylates, review