Abstract
Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be caused by adverse drug reactions. Several medications have been shown to have cardiotoxic effects. Among those therapeutic agents, anti-inflammatory drugs, including exogenous glucocorticoids, nonsteroidal anti-inflammatory drugs and biologics, which are used to treat a broad range of diseases that are associated with inflammatory processes, are widely prescribed in clinical practice. In this review, we discuss insights from experimental models on the beneficial and cardiotoxic effects of anti-inflammatory drugs.
Keywords: Glucocorticoids, NSAIDs, biologics, heart failure, ischemia/reperfusion, cardiac hypertrophy, cardiotoxic drugs, experimental models
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models
Volume: 12 Issue: 1
Author(s): Nolwenn Merlet, David Busseuil, Eric Rheaume and Jean-Claude Tardif
Affiliation:
Keywords: Glucocorticoids, NSAIDs, biologics, heart failure, ischemia/reperfusion, cardiac hypertrophy, cardiotoxic drugs, experimental models
Abstract: Although heart failure is predominantly caused by cardiovascular conditions such as hypertension, coronary heart disease and valvular heart disease, it can also be caused by adverse drug reactions. Several medications have been shown to have cardiotoxic effects. Among those therapeutic agents, anti-inflammatory drugs, including exogenous glucocorticoids, nonsteroidal anti-inflammatory drugs and biologics, which are used to treat a broad range of diseases that are associated with inflammatory processes, are widely prescribed in clinical practice. In this review, we discuss insights from experimental models on the beneficial and cardiotoxic effects of anti-inflammatory drugs.
Export Options
About this article
Cite this article as:
Merlet Nolwenn, Busseuil David, Rheaume Eric and Tardif Jean-Claude, Cardiac Consequences of Anti-Inflammatory Drugs in Experimental Models, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2013; 12 (1) . https://dx.doi.org/10.2174/1871523011312010005
DOI https://dx.doi.org/10.2174/1871523011312010005 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Current Role of Proteomics in Pancreatic Cancer Biomarkers Research
Current Proteomics Mental Health Patients at High Risk for Obesity, Type 2 Diabetes, and Cardiovascular Disease: An Australian Perspective
Current Hypertension Reviews Post-stroke Depression Therapy: Where are we now?
Current Neurovascular Research The First Line of Defense Against Cardiac Hypertrophy
Current Molecular Medicine Peripartum Cardiomyopathy: Current State of Knowledge, New Developments and Future Directions
Current Cardiology Reviews Omega-3 Polyunsaturated Fatty Acids and Cancer
Anti-Cancer Agents in Medicinal Chemistry Pituitary Dysfunction as a Cause of Cardiovascular Disease
Current Pharmaceutical Design Antioxidants in Treating Pathologies Involving Oxidative Damage: An Update on Medicinal Chemistry and Biological Activity of Stobadine and Related Pyridoindoles
Current Medicinal Chemistry Individual Differences in the Neurobiology of Social Stress: Implications for Depression-Cardiovascular Disease Comorbidity
Current Neuropharmacology Dimensional Assessment of Hypochondriacal Fears and Beliefs
Current Psychiatry Reviews Hydrolases in Organic Chemistry. Recent Achievements in the Synthesis of Pharmaceuticals
Current Organic Chemistry The Impact of Dietary Habits and Nutritional Deficiencies in Urban African Patients Living with Heart Failure in Soweto, South Africa – A Review
Endocrine, Metabolic & Immune Disorders - Drug Targets Goat Milk Frozen Yogurt Caja (Spondias mombin L.) Flavor: Development and Sensory Acceptance of an Exotic Food
Current Nutrition & Food Science The Role of Adenosine in Alzheimers Disease
Current Neuropharmacology Fetal Undernutrition and the Programming of Blood Pressure
Current Nutrition & Food Science Endothelial Dysfunction and Atherosclerosis: Focus on Novel Therapeutic Approaches
Recent Patents on Cardiovascular Drug Discovery Zebrafish: A Complete Animal Model for In Vivo Drug Discovery and Development
Current Drug Metabolism Severe Hyponatremia and Other Electrolyte Disturbances Associated with Indapamide
Current Drug Safety A New Validated HPLC-DAD Method for Estimation of Solasodine from Solanum nigrum Linn. Extracts and Formulations
The Natural Products Journal Virtual Screening on Analogs of 2 Methyl Heptyl Isonicotinate as GlmU Inhibitors of Mycobacterium tuberculosis
Current Enzyme Inhibition