Abstract
The present study was aimed to determine the therapeutic potential of novel carriers to deliver insulin into brain, by passing the BBB. PLGA nanoparticles and PEGylated PLGA nanoparticles were prepared by double emulsification method. PEG-PLGA copolymer was synthesized and characterized by FTIR, NMR and Mass spectroscopies. The release profiles of drug in various formulations were studied in PBS (pH 7.4). Results showed more sustained release of drug with Tween-80 based formulation in comparison with Tween-20 and PVA based formulations. A more sustained and extended release was observed upon chitosan coating of PEG-PLGA nanoparticles. Blood glucose level monitoring suggested that glucose level was not decreased significally in the peripheral region (p>0.05), when chitosan coated insulin loaded PEGylated nanoparticle was administered by intranasal route. This outcome in particular along with expected mucoadhesive and targeted benefit associated with chitosan based formulation drove us to conclude this formulation to be working best for the undertaken brain delivery issue.
Keywords: Co-polymer nanoparticle, insulin, Alzheimer, biodistribution study, restoration of memory signaling
Current Nanoscience
Title:Nanoparticulate Carrier Mediated Intranasal Delivery of Insulin for the Restoration of Memory Signaling in Alzheimer’s Disease
Volume: 9 Issue: 1
Author(s): Pankaj Dwivedi, Rakesh Kumar Tekade and Narendra Kumar Jain
Affiliation:
Keywords: Co-polymer nanoparticle, insulin, Alzheimer, biodistribution study, restoration of memory signaling
Abstract: The present study was aimed to determine the therapeutic potential of novel carriers to deliver insulin into brain, by passing the BBB. PLGA nanoparticles and PEGylated PLGA nanoparticles were prepared by double emulsification method. PEG-PLGA copolymer was synthesized and characterized by FTIR, NMR and Mass spectroscopies. The release profiles of drug in various formulations were studied in PBS (pH 7.4). Results showed more sustained release of drug with Tween-80 based formulation in comparison with Tween-20 and PVA based formulations. A more sustained and extended release was observed upon chitosan coating of PEG-PLGA nanoparticles. Blood glucose level monitoring suggested that glucose level was not decreased significally in the peripheral region (p>0.05), when chitosan coated insulin loaded PEGylated nanoparticle was administered by intranasal route. This outcome in particular along with expected mucoadhesive and targeted benefit associated with chitosan based formulation drove us to conclude this formulation to be working best for the undertaken brain delivery issue.
Export Options
About this article
Cite this article as:
Dwivedi Pankaj, Kumar Tekade Rakesh and Kumar Jain Narendra, Nanoparticulate Carrier Mediated Intranasal Delivery of Insulin for the Restoration of Memory Signaling in Alzheimer’s Disease, Current Nanoscience 2013; 9 (1) . https://dx.doi.org/10.2174/1573413711309010010
DOI https://dx.doi.org/10.2174/1573413711309010010 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Current Overview of Inorganic Nanoparticles for the Treatment of Central Nervous System (CNS) Diseases
Current Nanomaterials Biomarkers of Alzheimer’s Disease: An Overview of the Recent Inventions
Recent Patents on Biomarkers Advances in Bioconjugation
Current Organic Chemistry Compartmentalized Platforms for Neuro-Pharmacological Research
Current Neuropharmacology Validating SIFT-MS Analysis of Volatiles in Breath
Current Analytical Chemistry Adverse Drug Reactions in Critical Care Settings: A Systematic Review
Current Drug Safety HPV and Therapeutic Vaccines: Where are We in 2010?
Current Cancer Therapy Reviews Central Nervous System Involvement in Pediatric Rheumatic Diseases: Current Concepts in Treatment
Current Pharmaceutical Design Application of Chitosan and Propolis in Endodontic Treatment: A Review
Mini-Reviews in Medicinal Chemistry Quinolones: Action and Resistance Updated
Current Topics in Medicinal Chemistry Herpes Simplex Encephalitis: From Virus to Therapy
Infectious Disorders - Drug Targets A Transcriptomics Study to Elucidate the Toxicological Mechanism of Methylmercury Chloride in a Human Stem Cell Based In Vitro Test
Current Medicinal Chemistry MIANN Models in Medicinal, Physical and Organic Chemistry
Current Topics in Medicinal Chemistry Genetic Polymorphism and Tumor Immunotherapy
Current Pharmacogenomics Meet Our Editorial Board Member
Current Neuropharmacology Editorial [Hot topic: Central and Peripheral Metabolic Changes in Neurodegenerative Diseases (Guest Editor: Ana Cristina Rego)]
Current Drug Targets Targeting Telomerase for Cancer Therapy
Current Cancer Therapy Reviews Anti-inflammatory Potential of GSK-3 Inhibitors
Current Drug Targets Before and After Preeclampsia: What Biomarkers are there?
Current Women`s Health Reviews Computational Approaches for the Identification and Optimization of Src Family Kinases Inhibitors
Current Medicinal Chemistry