Abstract
Cellular senescence is a response to nonlethal intrinsic or extrinsic stress that results in persistent growth arrest with a distinct morphological and biochemical phenotype. The engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. Nevertheless, for many years, the role of senescence in opposing tumour growth in vivo had previously been underestimated. The potential role of cellular senescence in anti-cancer therapy may be particularly attractive in advanced age, because of the age-related changes occurring at the level of both tumor suppressor genes and immune functions. This review, which is focused on the impact of cellular senescence in aging and cancer, summarises the intrinsic pathways and the molecular and epigenetic changes involved in the induction of cellular senescence, and analyzes the changes occurring at the level of these pathways during aging and cancer.
Keywords: Cellular senescence, cancer, aging, extrinsic stress, growth arrest, tumour growth, age-related changes, tumor suppressor genes, epigenetic changes, immune functions
Current Pharmaceutical Design
Title:Impact of Cellular Senescence in Aging and Cancer
Volume: 19 Issue: 9
Author(s): Mauro Provinciali, Maurizio Cardelli, Francesca Marchegiani and Elisa Pierpaoli
Affiliation:
Keywords: Cellular senescence, cancer, aging, extrinsic stress, growth arrest, tumour growth, age-related changes, tumor suppressor genes, epigenetic changes, immune functions
Abstract: Cellular senescence is a response to nonlethal intrinsic or extrinsic stress that results in persistent growth arrest with a distinct morphological and biochemical phenotype. The engagement of senescence may represent a key component for therapeutic intervention in the eradication of cancer. Nevertheless, for many years, the role of senescence in opposing tumour growth in vivo had previously been underestimated. The potential role of cellular senescence in anti-cancer therapy may be particularly attractive in advanced age, because of the age-related changes occurring at the level of both tumor suppressor genes and immune functions. This review, which is focused on the impact of cellular senescence in aging and cancer, summarises the intrinsic pathways and the molecular and epigenetic changes involved in the induction of cellular senescence, and analyzes the changes occurring at the level of these pathways during aging and cancer.
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Cite this article as:
Provinciali Mauro, Cardelli Maurizio, Marchegiani Francesca and Pierpaoli Elisa, Impact of Cellular Senescence in Aging and Cancer, Current Pharmaceutical Design 2013; 19 (9) . https://dx.doi.org/10.2174/1381612811319090017
DOI https://dx.doi.org/10.2174/1381612811319090017 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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