Abstract
Patients with human immuno-deficiency virus (HIV)-infection have a high prevalence of abnormal bone metabolism and vitamin D deficiency. Vitamin D treatment has some benefit in patients with HIV infection. In this paper, we review the evidence for an association between vitamin D and HIV infection. Literature search was done from Medline. Genetic studies have provided the opportunity to determine which proteins link vitamin D to HIV pathology [i.e., the major histocompatibility complex class II molecules, vitamin D receptor, cytochrome P450, renin-angiotensin system, apolipoprotein E, liver X receptor, toll-like receptor, poly(ADP-ribosyl) polymerase-1, natural resistanceassociated macrophage protein 1, and the Sp1 promoter gene]. Vitamin D also exerts its effect on HIV through nongenomic factors, i.e., ultraviolet radiation exposure, matrix metalloproteinase, heme oxygenase-1, the prostaglandins, cyclooxygenase-2, and oxidative stress.
In conclusion, vitamin D may have a beneficial role in HIV. Calcitriol, 1α,25-dihydroxyvitamin D3 should be tested in HIV-infected population because of its active form of the vitamin D3 metabolite and modulates inflammatory cytokine expression. Further investigation with calcitriol in HIV is needed.
Keywords: Calcitriol, HIV, human immuno-deficiency virus, Vitamin D, infection, MHC, DRB1, VDR, AIDS, NRAMP1
Current HIV Research
Title:The Beneficial Role of Vitamin D in Human Immunodeficiency Virus Infection
Volume: 11 Issue: 1
Author(s): Khanh vinh quoc Luong and Lan Thi Hoang Nguyen
Affiliation:
Keywords: Calcitriol, HIV, human immuno-deficiency virus, Vitamin D, infection, MHC, DRB1, VDR, AIDS, NRAMP1
Abstract: Patients with human immuno-deficiency virus (HIV)-infection have a high prevalence of abnormal bone metabolism and vitamin D deficiency. Vitamin D treatment has some benefit in patients with HIV infection. In this paper, we review the evidence for an association between vitamin D and HIV infection. Literature search was done from Medline. Genetic studies have provided the opportunity to determine which proteins link vitamin D to HIV pathology [i.e., the major histocompatibility complex class II molecules, vitamin D receptor, cytochrome P450, renin-angiotensin system, apolipoprotein E, liver X receptor, toll-like receptor, poly(ADP-ribosyl) polymerase-1, natural resistanceassociated macrophage protein 1, and the Sp1 promoter gene]. Vitamin D also exerts its effect on HIV through nongenomic factors, i.e., ultraviolet radiation exposure, matrix metalloproteinase, heme oxygenase-1, the prostaglandins, cyclooxygenase-2, and oxidative stress.
In conclusion, vitamin D may have a beneficial role in HIV. Calcitriol, 1α,25-dihydroxyvitamin D3 should be tested in HIV-infected population because of its active form of the vitamin D3 metabolite and modulates inflammatory cytokine expression. Further investigation with calcitriol in HIV is needed.
Export Options
About this article
Cite this article as:
vinh quoc Luong Khanh and Thi Hoang Nguyen Lan, The Beneficial Role of Vitamin D in Human Immunodeficiency Virus Infection, Current HIV Research 2013; 11 (1) . https://dx.doi.org/10.2174/1570162X11311010009
DOI https://dx.doi.org/10.2174/1570162X11311010009 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs)
Current Medicinal Chemistry Autophagy Inhibition in Childhood Nephroblastoma and the Therapeutic Significance
Current Cancer Drug Targets <i>Click</i> Reaction in the Synthesis of Dendrimer Drug-delivery Systems
Current Medicinal Chemistry Baculovirus as Vaccine Vectors
Current Gene Therapy Natures Lessons to Design an Effective, Rational and Selective Drug for Soft Tissue Sarcoma Treatment: The Ecteinascidins
Drug Design Reviews - Online (Discontinued) Applications of Nanosystems to Anticancer Drug Therapy (Part II. Dendrimers, Micelles, Lipid-based Nanosystems)
Recent Patents on Anti-Cancer Drug Discovery Lipid-based Nanoplatforms in Cancer Therapy: Recent Advances and Applications
Current Cancer Drug Targets Imaging of Hypoxia Using PET and MRI
Current Pharmaceutical Biotechnology Advances in Methods for Therapeutic Peptide Discovery, Design and Development
Current Pharmaceutical Biotechnology Phytoecdysteroids - From Isolation to Their Effects on Humans
Current Medicinal Chemistry Nur77 Family of Nuclear Hormone Receptors
Current Drug Targets - Inflammation & Allergy Discovery of a Small Molecule Inhibitor of the Interaction Between HIV-1 Proteins and Cellular Cofactors: A Novel Candidate Anti-HIV-1 Drug
Current Chemical Biology Possible Pathways of Hepatotoxicity Caused by Chemical Agents
Current Drug Metabolism Lanthionine Synthetase Component C-Like Protein 2: A New Drug Target for Inflammatory Diseases and Diabetes
Current Drug Targets Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy
Current Molecular Pharmacology A Review of Pediatric Mediastinal Masses and Castlemans Disease
Current Pediatric Reviews Current Status of the Non-nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1
Current Topics in Medicinal Chemistry Using Fragment-Based Technologies to Target Protein-Protein Interactions
Current Pharmaceutical Design Cytotoxic Effect of the Red Beetroot (Beta vulgaris L.) Extract Compared to Doxorubicin (Adriamycin) in the Human Prostate (PC-3) and Breast (MCF-7) Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Current Status on Natural Products with Antitumor Activity from Brazilian Marine Sponges
Current Pharmaceutical Biotechnology