Abstract
Background: We recently reported elevated cerebrospinal fluid (CSF) levels of soluble tumor necrosis factor (TNF) receptors and TNF-α converting enzyme (TACE) activity in subjects with Alzheimer’s disease (AD) in a Caucasian population. The TNF receptor-mediated signaling pathway contributes to the production of Aβ and the subsequent cytotoxicity that is observed in AD brains. However, whether the plasma levels of soluble TNF receptors (sTNFRs) are changed is still unclear in AD patients of Han descent.
Methods: In the present study, we analyzed the plasma sTNFR levels using commercially available immunoassay kits in 76 AD patients and 40 age- and sex-matched control subjects of Northern Han Chinese descent. Furthermore, the TACE activity was measured using a solution-based assay containing a fluorescently labeled TACE substrate. Results: AD patients exhibited higher levels of both sTNFR and TACE activity in their plasma compared with age- and sex-matched control subjects. The levels of sTNFR1 strongly correlated with the levels of sTNFR2 (rs =0.526, P<0.001). In addition, the levels of sTNFR1 were significantly correlated with TACE activity (rs = 0.308, P<0.01). Conclusion: These results suggest that sTNFRs and TACE activity might serve as potential peripheral diagnostic candidate biomarkers in AD.Keywords: Alzheimer’s disease, amyloid beta peptides, soluble tumor necrosis factor receptor, tumor necrosis factor converting enzyme
Current Alzheimer Research
Title:Elevated Plasma Levels of Soluble TNFRs and TACE Activity in Alzheimer's Disease Patients of Northern Han Chinese Descent
Volume: 10 Issue: 1
Author(s): Lin Bai, Ning Song, Jintai Yu, Lan Tan, Yong Shen, Junxia Xie and Hong Jiang
Affiliation:
Keywords: Alzheimer’s disease, amyloid beta peptides, soluble tumor necrosis factor receptor, tumor necrosis factor converting enzyme
Abstract: Background: We recently reported elevated cerebrospinal fluid (CSF) levels of soluble tumor necrosis factor (TNF) receptors and TNF-α converting enzyme (TACE) activity in subjects with Alzheimer’s disease (AD) in a Caucasian population. The TNF receptor-mediated signaling pathway contributes to the production of Aβ and the subsequent cytotoxicity that is observed in AD brains. However, whether the plasma levels of soluble TNF receptors (sTNFRs) are changed is still unclear in AD patients of Han descent.
Methods: In the present study, we analyzed the plasma sTNFR levels using commercially available immunoassay kits in 76 AD patients and 40 age- and sex-matched control subjects of Northern Han Chinese descent. Furthermore, the TACE activity was measured using a solution-based assay containing a fluorescently labeled TACE substrate. Results: AD patients exhibited higher levels of both sTNFR and TACE activity in their plasma compared with age- and sex-matched control subjects. The levels of sTNFR1 strongly correlated with the levels of sTNFR2 (rs =0.526, P<0.001). In addition, the levels of sTNFR1 were significantly correlated with TACE activity (rs = 0.308, P<0.01). Conclusion: These results suggest that sTNFRs and TACE activity might serve as potential peripheral diagnostic candidate biomarkers in AD.Export Options
About this article
Cite this article as:
Bai Lin, Song Ning, Yu Jintai, Tan Lan, Shen Yong, Xie Junxia and Jiang Hong, Elevated Plasma Levels of Soluble TNFRs and TACE Activity in Alzheimer's Disease Patients of Northern Han Chinese Descent, Current Alzheimer Research 2013; 10 (1) . https://dx.doi.org/10.2174/1567205011310010008
DOI https://dx.doi.org/10.2174/1567205011310010008 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Neural Correlates in Patients with Major Affective Disorders: An fMRI Study
CNS & Neurological Disorders - Drug Targets Editorial [Hot Topic New Clinical Indications of Antipsychotic Medications Guest Editors: Filippo Bogetto and Silvio Bellino]
Current Psychopharmacology The Endocannabinoid System and Huntingtons Disease
Current Drug Targets - CNS & Neurological Disorders Neuroprotective Effects of Exercise Treatments After Injury: The Dual Role of Neurotrophic Factors
Current Neuropharmacology Herbal and Traditional Chinese Medicine for the Treatment of Cardiovascular Complications in Diabetes Mellitus
Current Diabetes Reviews New Avenue of Research: Antiepileptic Drug and Estradiol Neuroprotection in Epilepsy
Recent Patents on CNS Drug Discovery (Discontinued) Management of Hypertension in the Acute Phase of Stroke
Current Hypertension Reviews HIV Infection and Myocardial Infarction
Current HIV Research Artificial Intelligence, Big Data and Machine Learning Approaches in Precision Medicine & Drug Discovery
Current Drug Targets Synthesis and In Vitro Evaluation of New Tacrine Derivates-Bis-Alkylene Linked 7-MEOTA
Letters in Organic Chemistry D1 and Functionally Selective Dopamine Agonists as Neuroprotective Agents in Parkinsons Disease
CNS & Neurological Disorders - Drug Targets Neuroinflammation: Microglial Activation During Sepsis
Current Neurovascular Research A Case of Ischemic Stroke in Acute Promyelocytic Leukemia at Initial Presentation: Relevance of All-Trans Retinoic Acid Treatment
Cardiovascular & Hematological Disorders-Drug Targets Fibrinolytic Enzymes From Extremophilic Microorganisms in the Development of New Thrombolytic Therapies: Technological Prospecting
Recent Patents on Biotechnology Development and Validation of a Fluorescence-Based HTS Assay for the Identification of P/Q-Type Calcium Channel Blockers
Combinatorial Chemistry & High Throughput Screening Antioxidant and Acetylcholinesterase Inhibitory Potential of Thai Medicinal Plants
Current Nutrition & Food Science Urinary Metabolomics Reveals Alterations of Aromatic Amino Acid Metabolism of Alzheimer’s Disease in the Transgenic CRND8 Mice
Current Alzheimer Research Serum Amyloid Beta Peptides in Patients with Dementia and Age-Matched Non-Demented Controls as Detected by Surface-Enhanced Laser Desorption Ionisation-Time of Flight Mass Spectrometry (SELDI-TOF MS)
Current Clinical Pharmacology Relation of Obesity to Cognitive Function: Importance of Central Obesity and Synergistic Influence of Concomitant Hypertension. The Framingham Heart Study
Current Alzheimer Research A Novel Perspective on Tau in Alzheimers Disease
Current Alzheimer Research