Abstract
Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional processes based on structural data.
Keywords: Cell division, structure, phosphorylation, peptidoglycan, Bacterial Cell Division, STPKs, KINASE DOMAIN, PASTA, MviN, EXTRACELLULAR REGION
Current Protein & Peptide Science
Title:Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective
Volume: 13 Issue: 8
Author(s): Alessia Ruggiero, Paola De Simone, Giovanni Smaldone, Flavia Squeglia and Rita Berisio
Affiliation:
Keywords: Cell division, structure, phosphorylation, peptidoglycan, Bacterial Cell Division, STPKs, KINASE DOMAIN, PASTA, MviN, EXTRACELLULAR REGION
Abstract: Recent genetic, biochemical and structural studies have established that eukaryotic-like Ser/Thr protein-kinases are critical mediators of developmental changes and host pathogen interactions in bacteria. Although with lower abundance compared to their homologues from eukaryotes, Ser/Thr protein-kinases are widespread in gram-positive bacteria. These data underline a key role of reversible Ser/Thr phosphorylation in bacterial physiology and virulence. Numerous studies have revealed how phosphorylation/dephosphorylation of Ser/Thr protein-kinases governs cell division and cell wall biosynthesis and that Ser/Thr protein kinases are responsible for distinct phenotypes, dependent on different environmental signals. In this review we discuss the current understandings of Ser/Thr protein-kinases functional processes based on structural data.
Export Options
About this article
Cite this article as:
Ruggiero Alessia, De Simone Paola, Smaldone Giovanni, Squeglia Flavia and Berisio Rita, Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective, Current Protein & Peptide Science 2012; 13 (8) . https://dx.doi.org/10.2174/1389203711213080005
DOI https://dx.doi.org/10.2174/1389203711213080005 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
Call for Papers in Thematic Issues
Advancements in Proteomic and Peptidomic Approaches in Cancer Immunotherapy: Unveiling the Immune Microenvironment
The scope of this thematic issue centers on the integration of proteomic and peptidomic technologies into the field of cancer immunotherapy, with a particular emphasis on exploring the tumor immune microenvironment. This issue aims to gather contributions that illustrate the application of these advanced methodologies in unveiling the complex interplay ...read more
Nutrition and Metabolism in Musculoskeletal Diseases
The musculoskeletal system consists mainly of cartilage, bone, muscles, tendons, connective tissue and ligaments. Balanced metabolism is of vital importance for the homeostasis of the musculoskeletal system. A series of musculoskeletal diseases (for example, sarcopenia, osteoporosis) are resulted from the dysregulated metabolism of the musculoskeletal system. Furthermore, metabolic diseases (such ...read more
Protein Folding, Aggregation and Liquid-Liquid Phase Separation
Protein folding, misfolding and aggregation remain one of the main problems of interdisciplinary science not only because many questions are still open, but also because they are important from the point of view of practical application. Protein aggregation and formation of fibrillar structures, for example, is a hallmark of a ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Psoriatic Arthritis – Review of the Immunologic, Clinic and Therapeutic Aspects of an Inflammatory Systemic Disease
Current Rheumatology Reviews Randomized Clinical Trials in Children - Ethical and Methodological Issues
Current Pharmaceutical Design In Search of New Cures for Tuberculosis
Medicinal Chemistry Inhalation Delivery of Host Defense Peptides (HDP) using Nano- Formulation Strategies: A Pragmatic Approach for Therapy of Pulmonary Ailments
Current Protein & Peptide Science Challenges Associated with Current and Future TB Treatment
Infectious Disorders - Drug Targets 4-Mer Hyaluronan Oligosaccharides Stimulate Inflammation Response in Synovial Fibroblasts in Part via TAK-1 and in Part via p38-MAPK
Current Medicinal Chemistry Computational Methods for Protein-Protein Interaction and their Application
Current Protein & Peptide Science Small Molecules Modulating Biogenesis or Processing of microRNAs with Therapeutic Potentials
Current Medicinal Chemistry Advances in the Chemistry of Saccharins: From Synthetic Novelties Towards Biologically Active Compounds
Current Medicinal Chemistry Targeted Anti Bacterial Therapy
Infectious Disorders - Drug Targets Involvement of IL-1R/TLR Signalling in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
Current Molecular Medicine The Role of Machine Learning in Centralized Authorization Process of Nanomedicines in European Union
Current Topics in Medicinal Chemistry Synthesis and In Vitro Anti-Tubercular Activity of a Series of N- (Disubstitutedbenzoyl)Isoniazid Derivatives
Letters in Drug Design & Discovery An Update on Natural Occurrence and Biological Activity of Chromones
Current Medicinal Chemistry Synthesis, DNA Binding, Docking and Photoclevage Studies of Novel Benzo[b][1,8]naphthyridines
Medicinal Chemistry The -omics Era- Toward a Systems-Level Understanding of Streptomyces
Current Genomics Phenothiazine: A Better Scaffold against Tuberculosis
Mini-Reviews in Medicinal Chemistry Toxicogenomics to Improve Comprehension of the Mechanisms Underlying Responses of In Vitro and In Vivo Systems to Nanomaterials: A Review
Current Genomics Liposomes: Targeted and Controlled Delivery System
Drug Delivery Letters An Evolving Role of Piperazine Moieties in Drug Design and Discovery
Mini-Reviews in Medicinal Chemistry