Abstract
Ion channels are integral membrane proteins that are responsible for most physiological functions including the electrical activity of excitable cells. Their expression and function are regulated by a variety of means including microRNAs (miRNAs). MicroRNAs are small non coding RNAs, 22 nucleotides in length, involved in regulation of gene expression. In this study, we attempt to predict the miRNA targets of ion channel genes conserved across 4 species using TargetScan algorithm. From the results, many miRNA targets were found to be conserved among mammals. The expression profile of identified miRNA targets of certain genes that are implicated in channelopathies of brain, heart and skeletal muscle in Homo sapiens are explored. Further a final correlation of channel genes and miRNAs expressed in specific tissues is obtained by comparison of expression profiles using mimiRNA. miR-302a and miR-9 were found to be positively correlated with many channelopathy associated genes, while miR-143 and miR-29a were predicted to exhibit negative correlation. In this paper we summarize a list of all possible miRNAs linked with channelopathies.
Keywords: Channelopathy, ion channels, microRNA, target prediction, mRNA deadenylation, Alzheimer's disease, virus infection, myocardial infarction, cancer, cell proliferation
Current Bioinformatics
Title:A Computational Prediction of Conserved MicroRNA Targets of Ion Channels in Vertebrates
Volume: 8 Issue: 1
Author(s): Priyadarshan Kathirvel, Gopal Ramesh Kumar and Kavitha Sankaranarayanan
Affiliation:
Keywords: Channelopathy, ion channels, microRNA, target prediction, mRNA deadenylation, Alzheimer's disease, virus infection, myocardial infarction, cancer, cell proliferation
Abstract: Ion channels are integral membrane proteins that are responsible for most physiological functions including the electrical activity of excitable cells. Their expression and function are regulated by a variety of means including microRNAs (miRNAs). MicroRNAs are small non coding RNAs, 22 nucleotides in length, involved in regulation of gene expression. In this study, we attempt to predict the miRNA targets of ion channel genes conserved across 4 species using TargetScan algorithm. From the results, many miRNA targets were found to be conserved among mammals. The expression profile of identified miRNA targets of certain genes that are implicated in channelopathies of brain, heart and skeletal muscle in Homo sapiens are explored. Further a final correlation of channel genes and miRNAs expressed in specific tissues is obtained by comparison of expression profiles using mimiRNA. miR-302a and miR-9 were found to be positively correlated with many channelopathy associated genes, while miR-143 and miR-29a were predicted to exhibit negative correlation. In this paper we summarize a list of all possible miRNAs linked with channelopathies.
Export Options
About this article
Cite this article as:
Kathirvel Priyadarshan, Ramesh Kumar Gopal and Sankaranarayanan Kavitha, A Computational Prediction of Conserved MicroRNA Targets of Ion Channels in Vertebrates, Current Bioinformatics 2013; 8 (1) . https://dx.doi.org/10.2174/1574893611308010015
DOI https://dx.doi.org/10.2174/1574893611308010015 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Targeting the NMDA Receptor for Fear-Related Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Pharmacological Perspectives of Ayurvedic Herbs <i>viz. Alstonia scholaris</i> L., <i>Picrorhiza kurroa, Swertia chirata</i> and <i>Caesalpinia crista</i> Against COVID- 19: A Mini-Review
Mini-Reviews in Organic Chemistry Chaperone-like Activity of alpha-Crystallin and Other Small Heat Shock Proteins
Current Protein & Peptide Science Immunomodulatory and Anti-Inflammatory Activities of Statins
Endocrine, Metabolic & Immune Disorders - Drug Targets Non-Analgesic Effects of Opioids: Opioid-induced Respiratory Depression
Current Pharmaceutical Design Respiratory Tolerance in the Protection Against Asthma
Current Drug Targets - Inflammation & Allergy Theory of Mind is Just Behavior
Current Psychiatry Reviews Antihypertensive Therapy in Children: Differences in Medical Approach Between the United States and Europe
Current Medicinal Chemistry GluVII:06 - A Highly Conserved and Selective Anchor Point for Non-Peptide Ligands in Chemokine Receptors
Current Topics in Medicinal Chemistry Docosahexaenoic Acid-Phosphatidylcholine Improves Cognitive Deficits in an Aβ<sub>23-35</sub>-Induced Alzheimer’s Disease Rat Model
Current Topics in Medicinal Chemistry Detection and Diagnosis of Model Parameter and Noise Variance Changes Using Sliding Windows Approach
Recent Patents on Signal Processing (Discontinued) Aptamers as Innovative Diagnostic and Therapeutic Agents in the Central Nervous System
CNS & Neurological Disorders - Drug Targets Meet Our Editorial Board Member
Current Alzheimer Research The Role of Natural Products in the Ligand Deorphanization of TRP Channels
Current Pharmaceutical Design Serotonin Selective Reuptake Inhibitors (SSRIs) and Female Sexual Dysfunction (FSD): Hypothesis on its Association and Options of Treatment
Current Drug Targets Methylphenidate on Cognitive Improvement in Patients with Traumatic Brain Injury: A Meta-Analysis
Current Neuropharmacology Quantum Chemical Approaches: Semiempirical Molecular Orbital and Hybrid Quantum Mechanical/Molecular Mechanical Techniques
Current Pharmaceutical Design Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies
Current Topics in Medicinal Chemistry A Study of Applications of Machine Learning Based Classification Methods for Virtual Screening of Lead Molecules
Combinatorial Chemistry & High Throughput Screening Role of Granulocyte-colony Stimulating Factor in the Protection of Cerebral Vascular Endothelium, White Matter, and Cognition
Current Neurovascular Research