Abstract
The health effects of air pollution have been subject to intense study in recent years. These effects have been found in short-term studies, which relate day-to-day variations in air pollution and health, and long-term studies, which have followed cohorts of exposed individuals over time. Epidemiological evidence has concurred with clinical and experimental evidence to correlate current levels of ambient air pollution, both indoors and outdoors, with respiratory effects. The association between ambient air pollution exposure and lung cancer risk indicates that long-term exposure to air pollution may cause lung cancer. In the 1950s evidence of an ongoing epidemic of lung cancer in the United States and Europe led researchers to examine the role of outdoor air pollution, which was considered by some to be a likely cause. This concern is based on the fact that known carcinogens continue to be released into outdoor air from industrial sources, power plants, and motor vehicles. The present article reviews the epidemiologic evidence for this association and discusses the limitations of current studies for estimating the lung cancer risk in the general population. It also identifies research needs and suggests possible approaches to addressing outstanding questions like the causality assessment, which can benefit from biomarker research.
Keywords: Air pollution, ambient air, epidemiology, motor vehicle, traffic, lung cancer, polycyclic aromatic hydrocarbons, biomarker, review.
Current Respiratory Medicine Reviews
Title:Air Pollution and Lung Cancer
Volume: 8 Issue: 6
Author(s): Sagrario Mayoralas-Alises and Salvador Diaz-Lobato
Affiliation:
Keywords: Air pollution, ambient air, epidemiology, motor vehicle, traffic, lung cancer, polycyclic aromatic hydrocarbons, biomarker, review.
Abstract: The health effects of air pollution have been subject to intense study in recent years. These effects have been found in short-term studies, which relate day-to-day variations in air pollution and health, and long-term studies, which have followed cohorts of exposed individuals over time. Epidemiological evidence has concurred with clinical and experimental evidence to correlate current levels of ambient air pollution, both indoors and outdoors, with respiratory effects. The association between ambient air pollution exposure and lung cancer risk indicates that long-term exposure to air pollution may cause lung cancer. In the 1950s evidence of an ongoing epidemic of lung cancer in the United States and Europe led researchers to examine the role of outdoor air pollution, which was considered by some to be a likely cause. This concern is based on the fact that known carcinogens continue to be released into outdoor air from industrial sources, power plants, and motor vehicles. The present article reviews the epidemiologic evidence for this association and discusses the limitations of current studies for estimating the lung cancer risk in the general population. It also identifies research needs and suggests possible approaches to addressing outstanding questions like the causality assessment, which can benefit from biomarker research.
Export Options
About this article
Cite this article as:
Mayoralas-Alises Sagrario and Diaz-Lobato Salvador, Air Pollution and Lung Cancer, Current Respiratory Medicine Reviews 2012; 8 (6) . https://dx.doi.org/10.2174/1573398X11208060004
DOI https://dx.doi.org/10.2174/1573398X11208060004 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
Call for Papers in Thematic Issues
Exposure to PM2.5 components is associated with respiratory diseases
Through continuous research on the relationship between risk factors and health, it has been found that air pollution, especially atmospheric particulate matter pollution, has become one of the main sources of global disease burden. From 1990 to 2022, the concentration of atmospheric particulate matter pollution has increased by more than ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Tyrosine Kinase Mutations in Human Cancer
Current Molecular Medicine Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents
Mini-Reviews in Medicinal Chemistry Nanoparticles for Cancer Targeting: Current and Future Directions
Current Drug Delivery Too Much of a Good Thing: Suicide Prevention Promotes Chemoresistance in Ovarian Carcinoma
Current Cancer Drug Targets Lipoxygenase (LOX) Pathway: A Promising Target to Combat Cancer
Current Pharmaceutical Design Molecular Imaging with Small Animal PET/CT
Current Medical Imaging Metal Nanoparticle-Based Detection for DNA Analysis
Current Pharmaceutical Biotechnology Induction of HT-29 Colon Cancer Cells Apoptosis by Pyrogallol with Growth Inhibiting Efficacy Against Drug-Resistant Helicobacter pylori
Anti-Cancer Agents in Medicinal Chemistry Ubiquitination in Rho Signaling
Current Topics in Medicinal Chemistry An Update on JAK Inhibitors
Current Medicinal Chemistry New Molecules and Strategies in the Field of Anticancer Agents
Current Medicinal Chemistry - Anti-Cancer Agents Phosphorothioate Oligonucleotides: Effectiveness and Toxicity
Current Drug Targets Strategies for Increasing the Solubility and Bioavailability of Anticancer Compounds: β-Lapachone and Other Naphthoquinones
Current Pharmaceutical Design Dietary Agents for Prostate Cancer Chemoprevention: An Overview
Current Cancer Therapy Reviews Cross Talk between the Cardiovascular and Nervous Systems:Neurotrophic Effects of Vascular Endothelial Growth Factor (VEGF) and Angiogenic Effects of Nerve Growth Factor (NGF)-Implications in Drug Development
Current Pharmaceutical Design Neurodegeneration in the Brain Tumor Microenvironment: Glutamate in the Limelight
Current Neuropharmacology The Role of Survivin for Radiation Oncology: Moving Beyond Apoptosis Inhibition
Current Medicinal Chemistry PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters In Vivo
Current Drug Metabolism Histone Deacetylase Inhibitors In Inflammatory Disease
Current Topics in Medicinal Chemistry Ethanolic Extract of Berberis Vulgaris Fruits Inhibits the Proliferation of MCF-7 Breast Cancer Cell Line Through Induction of Apoptosis
Infectious Disorders - Drug Targets