Abstract
This review summarizes the progress that has been made recently in the medicinal chemistry of cantharidin, a potent antitumor agent from traditional Chinese medicine. Thousands of analogs have been synthesized on the basis of cantharidin, a part of which shows excellent properties, in particular, norcantharidin and norcantharimide. Despite the enormous efforts made, the intriguing bioactivities, mechanism, indications, and their interplay are still ill-defined. This review provides our up-to-date understanding in connection with the therapeutic use, mechanism, structure-activity relationship (SAR) and interesting properties of cantharidin analogs. Considerable development in the design of cantharidin analogs, in combination with mechanistic studies, has laid a foundation for transforming novel antitumor drugs into the clinic.
Keywords: Cantharidin, norcantharidin, antitumor, structure-activity relationship, medicinal chemistry, antitumor agent, norcantharimide, enormous efforts, mechanistic studies, intriguing bioactivities
Current Medicinal Chemistry
Title:Cantharidin as an Antitumor Agent: A Retrospective Review
Volume: 20 Issue: 2
Author(s): L.P. Deng, J. Dong, H. Cai and W. Wang
Affiliation:
Keywords: Cantharidin, norcantharidin, antitumor, structure-activity relationship, medicinal chemistry, antitumor agent, norcantharimide, enormous efforts, mechanistic studies, intriguing bioactivities
Abstract: This review summarizes the progress that has been made recently in the medicinal chemistry of cantharidin, a potent antitumor agent from traditional Chinese medicine. Thousands of analogs have been synthesized on the basis of cantharidin, a part of which shows excellent properties, in particular, norcantharidin and norcantharimide. Despite the enormous efforts made, the intriguing bioactivities, mechanism, indications, and their interplay are still ill-defined. This review provides our up-to-date understanding in connection with the therapeutic use, mechanism, structure-activity relationship (SAR) and interesting properties of cantharidin analogs. Considerable development in the design of cantharidin analogs, in combination with mechanistic studies, has laid a foundation for transforming novel antitumor drugs into the clinic.
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Cite this article as:
Deng L.P., Dong J., Cai H. and Wang W., Cantharidin as an Antitumor Agent: A Retrospective Review, Current Medicinal Chemistry 2013; 20 (2) . https://dx.doi.org/10.2174/0929867311320020001
DOI https://dx.doi.org/10.2174/0929867311320020001 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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