Abstract
Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair. Despite progress in orthopaedic surgery, cell-based surgical therapies such as autologous chondrocyte transplantation (ACT) have been in clinical use for cartilage repair for over a decade but this approach has shown mixed results. Moreover, the lack of efficient modalities of treatment for large chondral defects has prompted research on cartilage tissue engineering combining cells, scaffold materials and environmental factors. This paper focuses on the main parameters in tissue engineering and in particular, on the potential of mesenchymal stem cells (MSCs) as an alternative to cells derived from patient tissues in autologous transplantation and tissue engineering. We discussed the prospects of using autologous chondrocytes or MSCs in regenerative medicine and summarized the advantages and disadvantages of these cells in articular cartilage engineering.
Keywords: Articular Cartilage, Bioengineering, Regenerative medicine, Scaffolds, Mesenchymal Stem cells, cartilage tissue, autologous chondrocyte transplantation (ACT), orthopaedic surgery, surgical therapies
Current Pharmaceutical Biotechnology
Title:Human Stem Cells and Articular Cartilage Tissue Engineering
Volume: 13 Issue: 15
Author(s): J-F. Stoltz, C. Huselstein, J. Schiavi, Y.Y. Li, D. Bensoussan, V. Decot and N. De Isla
Affiliation:
Keywords: Articular Cartilage, Bioengineering, Regenerative medicine, Scaffolds, Mesenchymal Stem cells, cartilage tissue, autologous chondrocyte transplantation (ACT), orthopaedic surgery, surgical therapies
Abstract: Injuries to articular cartilage are one of the most challenging issues of musculoskeletal medicine due to the poor intrinsic ability of this tissue for repair. Despite progress in orthopaedic surgery, cell-based surgical therapies such as autologous chondrocyte transplantation (ACT) have been in clinical use for cartilage repair for over a decade but this approach has shown mixed results. Moreover, the lack of efficient modalities of treatment for large chondral defects has prompted research on cartilage tissue engineering combining cells, scaffold materials and environmental factors. This paper focuses on the main parameters in tissue engineering and in particular, on the potential of mesenchymal stem cells (MSCs) as an alternative to cells derived from patient tissues in autologous transplantation and tissue engineering. We discussed the prospects of using autologous chondrocytes or MSCs in regenerative medicine and summarized the advantages and disadvantages of these cells in articular cartilage engineering.
Export Options
About this article
Cite this article as:
Stoltz J-F., Huselstein C., Schiavi J., Li Y.Y., Bensoussan D., Decot V. and De Isla N., Human Stem Cells and Articular Cartilage Tissue Engineering, Current Pharmaceutical Biotechnology 2012; 13 (15) . https://dx.doi.org/10.2174/138920112804724846
DOI https://dx.doi.org/10.2174/138920112804724846 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pleiotropic Effects of Nifedipine on Atherosclerosis
Current Pharmaceutical Design Biomarker Discovery in Clinical Proteomics: Strategies for Exposing Low Abundant Proteins
Current Proteomics Acknowledgements to Contributors:
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Potential Application of Non-flavonoid Phenolics in Diabetes: Antiinflammatory Effects
Current Medicinal Chemistry Management of COVID-19 very Elderly Patients in Nursing Homes and Long-Term Care Facilities: Description of a New Model and Experience in a Medicalized Nursing Home
Coronaviruses Gut Inflammation: Current Update on Pathophysiology, Molecular Mechanism and Pharmacological Treatment Modalities
Current Pharmaceutical Design A Systematic Review of Overweight, Obesity, and Type 2 Diabetes Among Asian American Subgroups
Current Diabetes Reviews Meet Our Editorial Board Member
Recent Patents on Inflammation & Allergy Drug Discovery A Critical Review of Atypical Antipsychotic Utilization: Comparing Monotherapy with Polypharmacy and Augmentation
Current Medicinal Chemistry Recent Trends in the Pharmacological Activity of Isoprenyl Phenolics
Current Medicinal Chemistry Pharmacological Management of Type 2 Diabetes Mellitus: An Update
Current Diabetes Reviews Liver Fatty Acid Binding Protein (L-FABP) as a Target for the Prevention of High Fat Diet Induced Obesity and Hepatic Steatosis
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) The Effects of Lipid-Regulating Therapy on Haemostatic Parameters
Current Pharmaceutical Design The Chemopreventive and Chemotherapeutic Potentials of Tea Polyphenols
Current Pharmaceutical Biotechnology Chemical Composition and <i>In vitro</i> Antidiabetic Effects of <i>Olea europaea</i> Linn. (Olive)
Current Bioactive Compounds Potentialities of Induced Pluripotent Stem (iPS) Cells for Treatment of Diseases
Current Molecular Medicine Screening Differential Hub Genes Related with the Hypoglycemic Effect of Quercetin Through Data Mining
Current Bioinformatics Leptin and the Cardiovascular System: A Review
Recent Patents on Cardiovascular Drug Discovery Attacking HIV Provirus: Therapeutic Strategies to Disrupt Persistent Infection
Infectious Disorders - Drug Targets Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity
Current Pharmaceutical Design