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Nanoscience & Nanotechnology-Asia

Editor-in-Chief

ISSN (Print): 2210-6812
ISSN (Online): 2210-6820

Hybrid Bioactive Hydrogels Containing Single-Walled Carbon Nanotubes Covalently Integrated via Strain-Promoted Azide-Alkyne Cycloaddition

Author(s): Jurgen Bachl, Thimo Huber, Dennis Kuhbeck, Eva-Maria Schon, Gabriele Brunner, Birgit Kraus, Jorg Heilmann, Julian A. Codelli, Carolyn R. Bertozzi, Carlos Cativiela and David Diaz Diaz

Volume 2, Issue 2, 2012

Page: [200 - 209] Pages: 10

DOI: 10.2174/2210681211202020200

Price: $65

Abstract

A non-photochemical and metal-free orthogonal route for the covalent incorporation of single-walled carbon nanotubes into a κ-carrageenan-based bioactive hydrogel scaffold is reported. The characterization of materials was carried out by usual analytical techniques and hybrid biohydrogels were evaluated for in vitro cytotoxicity on HeLa cell lines. The results revealed a significant antiproliferative effect instead of additional cytotoxicity with respect to native hydrogels.

Keywords: Single-walled carbon nanotubes, ‘click’ chemistry, strain-promoted reactions, hydrogels, cytotoxicity


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