Abstract
Antiplatelet therapy plays an important role in the management of atherosclerotic disease and numerous studies have shown their efficacy in the reduction of cardiovascular mortality and morbidity. Antiplatelets are given in patients subjected to lower limb bypass aiming not only to reduce cardiovascular mortality and morbidity but also improve graft patency. Various antiplatelet agents have been used for this purpose. The aim of this review article is to critically evaluate the existing evidence on the impact of antiplatelet therapy for maintaining infrainguinal graft patency and highlight the mechanisms involved along these lines.
Keywords: Antiplatelet agents, peripheral arterial disease, infrainguinal bypass, graft patency, aspirin, clopidogrel, ticlopidine, ticlopidine, Lower limb atherosclerosis, femoropopliteal
Current Vascular Pharmacology
Title:A Critical Analysis on the Impact of Antiplatelet Therapy in the Patency of Infrainguinal Bypass Grafts
Volume: 11 Issue: 1
Author(s): George S. Sfyroeras, Vassileios Saleptsis, Christos Argyriou, Georgios A. Antoniou, Frans L. Moll and Athanasios D. Giannoukas
Affiliation:
Keywords: Antiplatelet agents, peripheral arterial disease, infrainguinal bypass, graft patency, aspirin, clopidogrel, ticlopidine, ticlopidine, Lower limb atherosclerosis, femoropopliteal
Abstract: Antiplatelet therapy plays an important role in the management of atherosclerotic disease and numerous studies have shown their efficacy in the reduction of cardiovascular mortality and morbidity. Antiplatelets are given in patients subjected to lower limb bypass aiming not only to reduce cardiovascular mortality and morbidity but also improve graft patency. Various antiplatelet agents have been used for this purpose. The aim of this review article is to critically evaluate the existing evidence on the impact of antiplatelet therapy for maintaining infrainguinal graft patency and highlight the mechanisms involved along these lines.
Export Options
About this article
Cite this article as:
S. Sfyroeras George, Saleptsis Vassileios, Argyriou Christos, A. Antoniou Georgios, L. Moll Frans and D. Giannoukas Athanasios, A Critical Analysis on the Impact of Antiplatelet Therapy in the Patency of Infrainguinal Bypass Grafts, Current Vascular Pharmacology 2013; 11 (1) . https://dx.doi.org/10.2174/1570161111309010047
DOI https://dx.doi.org/10.2174/1570161111309010047 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
Call for Papers in Thematic Issues
Ischemic Cardiovascular Diseases: Mechanisms, Diagnosis and Therapy
Ischemic cardiovascular disease includes myocardial infarction, coronary atherosclerotic heart disease, angina pectoris, etc., constitute the leading cause of patient mortality by preventing tissues from getting sufficient oxygen and nutrients. Ischemic heart disease, as a clinical condition, is characterized by myocardial ischemia, causing an imbalance between myocardial blood supply and demand, ...read more
TREATMENT OF CARDIOVASCULAR DISEASE IN CHRONIC AND END STAGE KIDNEY DISEASE
Cardiovascular disease still remains the leading cause of death in Chronic and End Stage Kidney Disease, accounting for more than half of all deaths in dialysis patients. During the past decade, research has been focused on novel therapeutic agents that might delay or even reverse cardiovascular disease and vascular calcification, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Neuronal Nicotinic Receptors and Neuroprotection: Newer Ligands May Help us Understand their Role in Neurodegeneration
Medicinal Chemistry Reviews - Online (Discontinued) Nitric Oxide and Dietary Factors: Part III Minerals, Vitamins and Other Dietary and Lifestyle Factors
Vascular Disease Prevention (Discontinued) The Neuropeptide Systems and their Potential Role in the Treatment of Mammalian Retinal Ischemia: A Developing Story
Current Neuropharmacology Gender Differences in Autonomic Control of the Cardiovascular System
Current Pharmaceutical Design Adenosine and Stroke: Maximizing the Therapeutic Potential of Adenosine as a Prophylactic and Acute Neuroprotectant
Current Neuropharmacology Syndrome of Supine Hypertension with Orthostatic Hypotension: Pathophysiology and Clinical Approach
Current Cardiology Reviews Endoplasmic Reticulum Stress, Diabetes Mellitus, and Tissue Injury
Current Protein & Peptide Science The Role of Oxidative Stress in the Pathogenesis of Type 2 Diabetes Mellitus Micro- and Macrovascular Complications: Avenues for a Mechanistic-Based Therapeutic Approach
Current Diabetes Reviews Obstructive Sleep Apnea Syndrome: From Phenotype to Genetic Basis
Current Genomics Recent Advances in Exercise Testing
Current Cardiology Reviews Genetics of Polygenic Hypertension from Animal Models to Humans
Current Hypertension Reviews Haemodynamic Regulation of Gene Expression in Vascular Tissue Engineering
Current Vascular Pharmacology Pediatric Heart Failure in the Developing World
Reviews on Recent Clinical Trials Incremental Value of Two Dimensional Speckle Tracking Echocardiography in the Functional Assessment and Characterization of Subclinical Left Ventricular Dysfunction
Current Cardiology Reviews Homocysteine in Neurology: From Endothelium to Neurodegeneration
Current Nutrition & Food Science Vasculopathy in Hyperthyroid Rats and Targets for Drug Effects
Vascular Disease Prevention (Discontinued) Spirolactones: Recent Advances in Natural Products, Bioactive Compounds and Synthetic Strategies
Current Medicinal Chemistry Radiolabeled Compounds in Diagnosis of Infectious and Inflammatory Disease
Current Pharmaceutical Design Management of Blood Pressure and Heart Rate in Patients with Acute Stroke
Current Pharmaceutical Design The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review
Mini-Reviews in Medicinal Chemistry