Abstract
Biotransformation is a broad and constantly growing field of biotechnology, which encompasses enzymatic, microbial and biomimetic catalysis. Use of biocatalysis for some chemical synthesis steps has unique advantages over traditional chemistry, most notably the possibility of achieving higher product selectivity under mild process conditions. This review discusses critical aspects of biotransformation of toxic organic compounds and suggests some guidelines for experimental planning which could significantly impact product yield.
The relative effectiveness of bioconversion depends on the characteristics of microbes and their enzymes, nutritional conditions, environmental parameters (T, pH, pO2), exposure to chemicals which can inhibit or induce enzyme levels, effects of extreme environments (e.g., non-aqueous media), and the kind of product isolation techniques used. Some of these and other factors affecting the efficiency of biotransformation as well as the most promising approaches to transformations of troublesome compounds are described. Recent advances in the use of both synthetic and natural porphyrins as biomimetic catalysts for biotechnological purposes and chemical syntheses are also discussed.Keywords: Biomimetic catalysis, Biotransformation, Microorganisms, Organic compound, Porphyrins, Solvents
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
11