Abstract
The use of PSA (prostate-specific antigen) for its diagnostic utility in prostate cancer is a subject of discussion; however, due to its specificity to the prostate tissue, PSA remains a potential immunotherapy target. We developed a PSA-recombinant viral vector, adenovirus5-PSA (Ad5-PSA) that generated vigorous PSA-specific immune and antitumor responses in a prostate cancer mouse model. Using Ad5-PSA vaccine we successfully completed a Phase I clinical study and are conducting a Phase II trial. In this review, we summarize the clinical development of this Ad5-PSA vaccine as an immunotherapeutic agent and its potential utility for the treatment of prostate cancer.
Keywords: Ad5-PSA vaccine, prostate cancer, immunotherapy
Current Cancer Therapy Reviews
Title:Adenovirus/PSA (Ad5-PSA) Vaccination for Prostate Cancer: Pre-Clinical and Clinical Development
Volume: 8 Issue: 4
Author(s): Daniel Vaena and David Lubaroff
Affiliation:
Keywords: Ad5-PSA vaccine, prostate cancer, immunotherapy
Abstract: The use of PSA (prostate-specific antigen) for its diagnostic utility in prostate cancer is a subject of discussion; however, due to its specificity to the prostate tissue, PSA remains a potential immunotherapy target. We developed a PSA-recombinant viral vector, adenovirus5-PSA (Ad5-PSA) that generated vigorous PSA-specific immune and antitumor responses in a prostate cancer mouse model. Using Ad5-PSA vaccine we successfully completed a Phase I clinical study and are conducting a Phase II trial. In this review, we summarize the clinical development of this Ad5-PSA vaccine as an immunotherapeutic agent and its potential utility for the treatment of prostate cancer.
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Cite this article as:
Vaena Daniel and Lubaroff David, Adenovirus/PSA (Ad5-PSA) Vaccination for Prostate Cancer: Pre-Clinical and Clinical Development, Current Cancer Therapy Reviews 2012; 8 (4) . https://dx.doi.org/10.2174/1573394711208040271
DOI https://dx.doi.org/10.2174/1573394711208040271 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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